SynthesisNutrients2020
Duration of Lactation and Maternal Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis.
Synthesis in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05619601 (Gender Differences in Prevention Strategies and Therapeutic Adherence After Acute Myocardial Infarction - GENAMI PREVENTION), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gender Differences in Prevention Strategies and Therapeutic Adherence After Acute Myocardial Infarction - GENAMI PREVENTION
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Primary Care-Based Cardiovascular Disease Risk Management After Adverse Pregnancy Outcomes: a Narrative Review.Journal of general internal medicine · 2022Pooled it
- Metabolic Syndrome and Coronary Artery Disease Risk: A Meta-Analysis of Observational Studies.International journal of environmental research and public health · 2021Pooled it
- An Observational Study Protocol for Assessing Lactation Intensity and Reduction in the Prevalence of Metabolic Syndrome After a Maternal Complication of Pregnancy (LEMON Study).Journal of human lactation : official journal of International Lactation Consultant Association · 2026Observational
- The association between breastfeeding and prevalence of metabolic syndrome in women with a previous major pregnancy complication.Frontiers in global women's health · 2026Article
- Article
- Metabolic dysfunction-associated steatotic liver disease and pregnancy.The Journal of clinical investigation · 2025Review
- The Impact of Maternal Chronic Inflammatory Conditions on Breast Milk Composition: Possible Influence on Offspring Metabolic Programming.Nutrients · 2025Review
- Cardiometabolic Risk Clusters and Their Reproductive Correlates: A Latent Class Analysis of Indian Women.Global heart · 2025Article
- Improvements in Insulin Resistance and Glucose Metabolism Related to Breastfeeding Are Not Mediated by Subclinical Inflammation.Metabolites · 2024Article
- Lifestyle Factors Influencing Metabolic Syndrome after Adjusting for Socioeconomic Status and Female Reproductive Health Indicators: A National Representative Survey in Korean Pre- and Postmenopausal Women.Healthcare (Basel, Switzerland) · 2024Article
- Machine learning analysis for the association between breast feeding and metabolic syndrome in women.Scientific reports · 2024Article
- Association between parities and duration of breastfeeding and the severity of coronary artery disease in women above 30 years old age (A pilot study).Caspian journal of internal medicine · 2024Article
- The dynamic nexus: exploring the interplay of BMI before, during, and after pregnancy with Metabolic Syndrome (MetS) risk in Chinese lactating women.BMC public health · 2023Article
- The association of female reproductive factors with risk of metabolic syndrome in women from NHANES 1999-2018.BMC public health · 2023Article
- The interaction between CRY1 Polymorphism and Alternative Healthy Eating Index (AHEI) on cardiovascular risk factors in overweight women and women with obesity: a cross-sectional study.BMC endocrine disorders · 2023Article
- Lactation duration and lifetime progression to metabolic syndrome in women according to their history of gestational diabetes: a prospective longitudinal community-based cohort study.Journal of translational medicine · 2023Article
- Reproductive factors and metabolic syndrome among Chinese women aged 40 years and older.Journal of diabetes · 2023Article
- Breastfeeding duration and subsequent risk of mortality among US women: A prospective cohort study.EClinicalMedicine · 2022Article
- Perception and practice of breastfeeding in public in Poland.Journal of mother and child · 2021Article
- Management of Ischemic Heart Disease in Pregnancy.Current atherosclerosis reports · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease (CVD) is the leading cause of death of women across all ages, and targeting modifiable risk factors, such as those comprised in metabolic syndrome (MetS) (e.g., waist circumference, lipid profile, blood pressure, and blood glucose), is of great importance. An inverse association between lactation and CVD has been suggested, and lactation may decrease the risk of MetS. This systematic review and meta-analysis examined how lactation may affect the development and prevalence of MetS in women. A literature search was performed using Cinahl, Embase, Web of Science, and PubMed. A total of 1286 citations were identified, and finally, ten studies (two prospective and eight cross-sectional) were included. Seven studies (two prospective and five cross-sectional) revealed associations between lactation and MetS, suggesting that breastfeeding might prevent or improve metabolic health and have a protective role in MetS prevention. This protective role might be related to the duration of lactation; however, a lack of controlling for potential confounders, such as parity, might inflict the results. The pooled effect was non-conclusive. Additional research is required to further explore the duration of lactation and its potential role in improving or reversing MetS and its components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.