Evidence map›Paper›PMID 32899501›Full record

ReviewNutrients2020

Vitamin K and Kidney Transplantation.

Maria Fusaro, Laura Cosmai, Pieter Evenepoel, Thomas L Nickolas, Angela M Cheung, Andrea Aghi, Giovanni Tripepi, Mario Plebani, Giorgio Iervasi, Roberto Vettor and 6 more

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Efficacy of vitamin K on bone fragility: puzzling findings from which we should learn how to design a rigorous study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  3. Review
  4. Article
  5. The Role of Vitamin K in CKD-MBD.Current osteoporosis reports · 2022
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 3 countries.

Maria FusaroNational Research Council (CNR), Institute of Clinical Physiology (IFC), 56124 Pisa, Italy.ORCID 0000-0001-9478-4851
Laura CosmaiNephrology Unit, ASST Fatebenefratelli Sacco, 20157 Milano, Italy.
Pieter EvenepoelLaboratory of Nephrology, Department of Immunology and Microbiology, B-3000 Leuven, Belgium.
Thomas L NickolasDivision of Nephrology, Department of Medicine, Columbia University, New York City, NY 10032, USA.ORCID 0000-0001-8870-1896
Angela M CheungDepartment of Medicine, University of Toronto, Toronto, ON M5S, Canada.
Andrea AghiDepartment of Medicine, Clinica Medica 1, University of Padua, 35128 Padova, PD, Italy.
Giovanni TripepiCNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Ospedali Riuniti, 89124 Reggio Calabria, Italy.
Mario PlebaniLaboratory Medicine Unit, Department of Medicine, University of Padua, 35128 Padova, Italy.
Giorgio IervasiNational Research Council (CNR), Institute of Clinical Physiology (IFC), 56124 Pisa, Italy.
Roberto VettorDepartment of Medicine, University of Padova, 35128 Padova, Italy.
Martina ZaninottoLaboratory Medicine Unit, Department of Medicine, University of Padua, 35128 Padova, Italy.
Maura RaveraPoliclinico San Martino, 16132 Genova, Italy.
Marina ForamittiDivisione di Nefrologia e Dialisi, Renal Department, ASST-Cremona, Largo Priori 1, 26100 Cremona, Italy.
Sandro GianniniDepartment of Medicine, Clinica Medica 1, University of Padua, 35128 Padova, PD, Italy.
Stefania SellaDepartment of Medicine, Clinica Medica 1, University of Padua, 35128 Padova, PD, Italy.
Maurizio GallieniNephrology Unit, ASST Fatebenefratelli Sacco, 20157 Milano, Italy.ORCID 0000-0002-2011-2160
University of Padua · ITASST Fatebenefratelli Sacco · ITColumbia University · USIstituti Ospitalieri di Cremona · ITIstituto di Fisiologia Clinica · ITLuigi Sacco Hospital · ITOspedale Policlinico San Martino · ITOspedali Riuniti di Foggia · ITUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The assessment of the vitamin K status and its effects on clinical outcomes in kidney transplantation (KT) patients has sparked interest, but it is still largely unfulfilled. In part, this is due to difficulties in laboratory measurements of vitamin K, especially K2 vitamers. Vitamin K status is currently best assessed by measuring undercarboxylated vitamin-K-dependent proteins. The relative contribution of vitamin K1 and K2 to the health status of the general population and CKD (chronic kidney disease) patients, including KT patients, is also poorly studied. Through a complete and first review of the existing literature, we summarize the current knowledge of vitamin K pathophysiology and its potential role in preventing KT complications and improving organ survival. A specific focus is placed on cardiovascular complications, bone fractures, and the relationship between vitamin K and cancer. Vitamin K deficiency could determine adverse outcomes, and KT patients should be better studied for vitamin K assessment and modalities of effective therapeutic approaches.

Indexed as

Cardiovascular DiseasesFractures, BoneHumansKidney TransplantationNeoplasmsNutritional StatusPostoperative ComplicationsPreoperative PeriodRenal Insufficiency, ChronicTreatment OutcomeVitamin K 1Vitamin K 2Vitamin K DeficiencyVitamin K 1Vitamin K 2bonecalcificationcancercardiovascular diseasefracturekidneymenaquinoneosteoporosisphylloquinonetransplantvitamin K

Identifiers

PMID32899501
PMCPMC7551925
OpenAlexW3083310903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.