Evidence map›Paper›PMID 32899497›Full record

ArticleInternational journal of molecular sciences2020

Insight into Molecular Mechanism for Activin A-Induced Bone Morphogenetic Protein Signaling.

Chen Xie, Wenjuan Jiang, Jerome J Lacroix, Yun Luo, Jijun Hao

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chen XieCollege of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766, USA.
Wenjuan JiangCollege of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0002-6360-3875
Jerome J LacroixGraduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0001-5687-0652
Yun LuoCollege of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA.
Jijun HaoCollege of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0002-6769-9069
Western University of Health Sciences · US

Funding

PHARMACOLOGICAL MODULATION OF PIEZO1 CHANNELSR01GM130834 · NIGMS · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI Yun Lyna LUO, Jerome Lacroix · 2019 to 2026
$2.8M
Biophysical Studies of Non-Invasive Brain Cell Stimulation with Focused UltrasoundR21NS101384 · NINDS · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI LACROIX, JEROME JACQUES · 2017 to 2018
$385k
NIGMS NIH HHS R01 GM130834NIH HHS R21NS101384NINDS NIH HHS R21 NS101384
6 · The paper itself

Abstract

Activins transduce the TGF-β pathway through a heteromeric signaling complex consisting of type I and type II receptors, and activins also inhibit bone morphogenetic protein (BMP) signaling mediated by type I receptor ALK2. Recent studies indicated that activin A cross-activates the BMP pathway through ALK2

Indexed as

Activin Receptors, Type IActivin Receptors, Type IIActivinsAnimalsBone Morphogenetic Protein Receptors, Type IBone Morphogenetic Protein Receptors, Type IIBone Morphogenetic ProteinsCell DifferentiationCell LineGene Expression RegulationHEK293 CellsHep G2 CellsHumansMiceOssification, HeterotopicPhosphorylationactivin AActivin Receptors, Type IActivin Receptors, Type IIActivinsACVR1 protein, humanBone Morphogenetic Protein Receptors, Type IBone Morphogenetic Protein Receptors, Type IIBone Morphogenetic ProteinsTransforming Growth Factor betaactivin AALK2BMPFibrodysplasia Ossificans ProgressivaFKBP12

Identifiers

PMID32899497
PMCPMC7555472
OpenAlexW3083067703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.