Evidence map›Paper›PMID 32899468›Full record

ArticleBrain sciences2020

Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls.

Mohamed B Abou-Donia, Elizabeth S Lapadula, Maxine H Krengel, Emily Quinn, Jessica LeClair, Joseph Massaro, Lisa A Conboy, Efi Kokkotou, Maria Abreu, Nancy G Klimas and 2 more

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Is Gulf War Illness a prolonged early phase tauopathy?Cytoskeleton (Hoboken, N.J.) · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. A cellular approach to understanding and treating Gulf War Illness.Cellular and molecular life sciences : CMLS · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Mohamed B Abou-DoniaDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Elizabeth S LapadulaDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Maxine H KrengelDepartment of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
Emily QuinnDepartments of Biostatistics and Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA.
Jessica LeClairDepartments of Biostatistics and Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA.
Joseph MassaroDepartments of Biostatistics and Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA.
Lisa A ConboyDepartment of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Efi KokkotouDepartment of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Maria AbreuDr. Kiran C. Patel College of Osteopathic Medicine, Institute for Neuroimmune Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA.
Nancy G KlimasDr. Kiran C. Patel College of Osteopathic Medicine, Institute for Neuroimmune Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA.
Daniel D NguyenDepartments of Biostatistics and Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA.
Kimberly SullivanDepartments of Biostatistics and Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA.ORCID 0000-0001-7940-6123
Boston University · USDuke Medical Center · USHarvard University · USNova Southeastern University · US

Funding

Congressionally Directed Medical Research Programs W81XWH-15-0640Congressionally Directed Medical Research Programs W81XWH-15-0641Congressionally Directed Medical Research Programs W81XWH-15-1-0695Congressionally Directed Medical Research Programs W81XWH-16-1-0528NIH HHS RO1 1A1065723
6 · The paper itself

Abstract

For the past 30 years, there has been a lack of objective tools for diagnosing Gulf War Illness (GWI), which is largely characterized by central nervous system (CNS) symptoms emerging from 1991 Gulf War (GW) veterans. In a recent preliminary study, we reported the presence of autoantibodies against CNS proteins in the blood of veterans with GWI, suggesting a potential objective biomarker for the disorder. Now, we report the results of a larger, confirmatory study of these objective biomarkers in 171 veterans with GWI compared to 60 healthy GW veteran controls and 85 symptomatic civilian controls (

Indexed as

CNS autoantibodiesetiologyGulf War Illnessirritable bowel syndromemyalgic encephalomyelitis/chronic fatigue syndrome

Identifiers

PMID32899468
PMCPMC7563126
OpenAlexW3083145854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.