Evidence map›Paper›PMID 32899431›Full record

ArticleInternational journal of molecular sciences2020

Oxidative Stress and Analysis of Selected SNPs of

Leonel Javeres Mbah Ntepe, Rabia Habib, Ngondi Judith Laure, Saqlain Raza, Eugenie Nepovimova, Kamil Kuca, Sajida Batool, Syed Muhammad Nurulain

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Leonel Javeres Mbah NtepeDepartment of Biosciences, COMSATS University Islamabad, Chak Shahzad, Islamabad 45550, Pakistan.ORCID 0000-0002-2273-2697
Rabia HabibDepartment of Biosciences, COMSATS University Islamabad, Chak Shahzad, Islamabad 45550, Pakistan.
Ngondi Judith LaureDepartment of Biochemistry, Yaoundé I University, Yaoundé 8024, Cameroon.
Saqlain RazaDepartment of Mathematics, COMSATS University Islamabad, Chak Shahzad, Islamabad 45550, Pakistan.
Eugenie NepovimovaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic.
Kamil KucaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic.ORCID 0000-0001-9664-1109
Sajida BatoolDepartment of Biosciences, COMSATS University Islamabad, Chak Shahzad, Islamabad 45550, Pakistan.ORCID 0000-0002-1806-389X
Syed Muhammad NurulainDepartment of Biosciences, COMSATS University Islamabad, Chak Shahzad, Islamabad 45550, Pakistan.ORCID 0000-0001-6146-1511
COMSATS University Islamabad · PKUniversity of Hradec Králové · CZUniversité de Yaoundé I · CM

Funding

COMSATS University Islamabad Internal projectThe World Academy of Sciences (TWAS) Internal projectUHK VT2019-2021
6 · The paper itself

Abstract

The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. However, several studies have shown that AChE inhibition alone cannot explain all the toxicological manifestations in prolonged exposure to OPs. The present study aimed to assess the status of antioxidants malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) (reduced), catalase, and ferric reducing antioxidant power (FRAP) in chronic OP-exposed groups from Cameroon and Pakistan. Molecular analysis of genetic polymorphisms (SNPs) of glutathione transferases (

Indexed as

Gene-Environment InteractionPolymorphism, Single NucleotideAcetylcholinesteraseAdolescentAdultButyrylcholinesteraseCameroonCatalaseEnvironmental ExposureFemaleGlutathioneGlutathione S-Transferase piGlutathione TransferaseGPI-Linked ProteinsHumansMaleAcetylcholinesteraseACHE protein, humanBCHE protein, humanButyrylcholinesteraseCatalaseGlutathioneGlutathione S-Transferase piglutathione S-transferase T1Glutathione TransferaseGPI-Linked ProteinsGSTP1 protein, humanMalondialdehydeOrganophosphorus CompoundsSIRT1 protein, humanSirtuin 1antioxidantscholinergic enzymesorganophosphatesSNPstoxicogenetics

Identifiers

PMID32899431
PMCPMC7503738
OpenAlexW3082152808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.