Evidence map›Paper›PMID 32899415›Full record

ArticleInternational journal of molecular sciences2020

Combined Treatment of Sulfonyl Chromen-4-Ones (CHW09) and Ultraviolet-C (UVC) Enhances Proliferation Inhibition, Apoptosis, Oxidative Stress, and DNA Damage against Oral Cancer Cells.

Sheng-Chieh Wang, Yen-Yun Wang, Li-Ching Lin, Meng-Yang Chang, Shyng-Shiou F Yuan, Jen-Yang Tang, Hsueh-Wei Chang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  11. Antioxidants (Basel, Switzerland) · 2021
    Article
  12. Journal of personalized medicine · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sheng-Chieh WangDepartment of Biomedical Science and Environmental Biology, PhD Program in Life Science, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Yen-Yun WangSchool of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Li-Ching LinDepartment of Radiation Oncology, Chi-Mei Foundation Medical Center, Tainan 71004, Taiwan.
Meng-Yang ChangDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0002-1983-8570
Shyng-Shiou F YuanCenter for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0002-4753-788X
Jen-Yang TangDepartment of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0002-5690-0708
Hsueh-Wei ChangDepartment of Biomedical Science and Environmental Biology, PhD Program in Life Science, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0003-0068-2366
Kaohsiung Medical University · TWChung Hwa University of Medical Technology · TWNational Sun Yat-sen University · TW

Funding

Health and welfare surcharge of tobacco products, the Ministry of Health and Welfare, Taiwan, Republic of China MOHW109-TDU-B-212-134016Kaohsiung Medical University Hospital KMUH108-8R67Kaohsiung Medical University Research Center KMU-TC108A04Ministry of Science and Technology, Taiwan MOST 108-2320-B-037-015-MY3; MOST 108-2314-B-037-020National Sun Yat-sen University-KMU Joint Research Project #NSYSUKMU 109-I002
6 · The paper itself

Abstract

The sensitizing effect of chromone-derived compounds on UVC-induced proliferation inhibition has not been comprehensively investigated so far. The subject of this study was to examine the proliferation change of oral cancer cells while using the combined treatment of UVC (254 nm) with our previously developed sulfonyl chromen-4-ones (CHW09), namely UVC/CHW09. Cell viability, apoptosis, oxidative stress, and DNA damage for the individual and combined treatments for UVC and/or CHW09 were examined in oral cancer Ca9-22 cells. In 24 h MTS assay, UVC (30 J/m

Indexed as

ApoptosisCell ProliferationDNA DamageOxidative StressUltraviolet RaysCell CycleCell MovementChromonesCombined Modality TherapyHumansMembrane Potential, MitochondrialMouth NeoplasmsPoly (ADP-Ribose) Polymerase-1Reactive Oxygen SpeciesTumor Cells, CulturedChromonesPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1Reactive Oxygen Speciesapoptosischromonecombined treatmentDNA damageoral cancerUVC

Identifiers

PMID32899415
PMCPMC7504536
OpenAlexW3081565112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.