Evidence map›Paper›PMID 32899288›Full record

ArticleMolecules (Basel, Switzerland)2020

Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and

Patrick Weber, Martin Thonhofer, Summer Averill, Gideon J Davies, Andres Gonzalez Santana, Philipp Müller, Seyed A Nasseri, Wendy A Offen, Bettina M Pabst, Eduard Paschke and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Developing Allosteric Chaperones forInternational journal of molecular sciences · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 3 countries.

Patrick WeberGlycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Martin ThonhoferGlycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Summer AverillGlycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Gideon J DaviesDepartment of Chemistry, University of York, Heslington, York YO10 5DD, North Yorkshire, UK.ORCID 0000-0002-7343-776X
Andres Gonzalez SantanaChemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Philipp MüllerInstitute of Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Seyed A NasseriChemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Wendy A OffenDepartment of Chemistry, University of York, Heslington, York YO10 5DD, North Yorkshire, UK.ORCID 0000-0002-2758-4531
Bettina M PabstLaboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria.
Eduard PaschkeLaboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria.
Michael SchalliGlycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Ana TorviscoInstitute of Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.ORCID 0000-0002-6203-7330
Marion TschernutterLaboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria.ORCID 0000-0002-7494-1896
Christina TysoeChemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Werner WindischhoferLaboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria.
Stephen G WithersChemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.ORCID 0000-0002-6722-5701
Andreas WolfsgruberGlycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Tanja M WrodniggGlycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Arnold E StützGlycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Graz University of Technology · ATMedical University of Graz · ATUniversity of British Columbia · CAUniversity of York · GB

Funding

Austrian Science Fund P 24815
6 · The paper itself

Abstract

Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid β-galactosidase inhibitors were prepared and their inhibitory and pharmacological chaperoning activities determined and compared with those of lipophilic analogs of the potent β-d-galactosidase inhibitor 4-

Indexed as

CrystallizationCyclopentanesEnzyme InhibitorsGalactosidasesHumansImino PyranosesLigandsLysosomesMolecular ChaperonesMolecular ConformationMutant ProteinsCyclopentanesEnzyme InhibitorsGalactosidasesImino PyranosesisofagomineLigandsMolecular ChaperonesMutant Proteins4-epi-isofagomineaminocyclopentanecarbasugargalactosidase inhibitorGM1-gangliosidosisiminoalditolpharmacological chaperone

Identifiers

PMID32899288
PMCPMC7504770
OpenAlexW3082573938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.