Evidence map›Paper›PMID 32899276›Full record

ArticleBiomolecules2020

The Relationship between the Level of Anterior Cingulate Cortex Metabolites, Brain-Periphery Redox Imbalance, and the Clinical State of Patients with Schizophrenia and Personality Disorders.

Amira Bryll, Wirginia Krzyściak, Paulina Karcz, Natalia Śmierciak, Tamas Kozicz, Justyna Skrzypek, Marta Szwajca, Maciej Pilecki, Tadeusz J Popiela

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Amira BryllDepartment of Radiology, Jagiellonian University Medical College, Kopernika 19, 31-501 Krakow, Poland.
Wirginia KrzyściakDepartment of Medical Diagnostics, Jagiellonian University, Medical College, Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0003-0452-295X
Paulina KarczDepartment of Electroradiology, Jagiellonian University Medical College, Michałowskiego 12, 31-126 Krakow, Poland.ORCID 0000-0002-3685-0723
Natalia ŚmierciakDepartment of Child and Adolescent Psychiatry, Faculty of Medicine, Jagiellonian University, Medical College, Kopernika 21a, 31-501 Krakow, Poland.
Tamas KoziczDepartment of Clinical Genomics, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Justyna SkrzypekDepartment of Medical Diagnostics, Jagiellonian University, Medical College, Medyczna 9, 30-688 Krakow, Poland.
Marta SzwajcaDepartment of Child and Adolescent Psychiatry, Faculty of Medicine, Jagiellonian University, Medical College, Kopernika 21a, 31-501 Krakow, Poland.
Maciej PileckiDepartment of Child and Adolescent Psychiatry, Faculty of Medicine, Jagiellonian University, Medical College, Kopernika 21a, 31-501 Krakow, Poland.
Tadeusz J PopielaDepartment of Radiology, Jagiellonian University Medical College, Kopernika 19, 31-501 Krakow, Poland.ORCID 0000-0002-6697-2449
Jagiellonian University · PLMayo Clinic · US

Funding

Jagiellonian University Medical College N41/DBS/000292
6 · The paper itself

Abstract

Schizophrenia is a complex mental disorder whose course varies with periods of deterioration and symptomatic improvement without diagnosis and treatment specific for the disease. So far, it has not been possible to clearly define what kinds of functional and structural changes are responsible for the onset or recurrence of acute psychotic decompensation in the course of schizophrenia, and to what extent personality disorders may precede the appearance of the appropriate symptoms. The work combines magnetic resonance spectroscopy imaging with clinical evaluation and laboratory tests to determine the likely pathway of schizophrenia development by identifying peripheral cerebral biomarkers compared to personality disorders. The relationship between the level of metabolites in the brain, the clinical status of patients according to International Statistical Classification of Diseases and Related Health Problems, 10th Revision ICD-10, duration of untreated psychosis (DUP), and biochemical indices related to redox balance (malondialdehyde), the efficiency of antioxidant systems (FRAP), and bioenergetic metabolism of mitochondria, were investigated. There was a reduction in the level of brain

Indexed as

AdultAntioxidantsAspartic AcidFemaleGlutamic AcidGyrus CinguliHumansMagnetic Resonance ImagingMaleMalondialdehydeOxidantsOxidation-ReductionOxidative StressPersonality DisordersPrognosisPsychotic DisordersAntioxidantsAspartic AcidGlutamic AcidMalondialdehydeOxidantsbrain metabolitesmagnetic resonance spectroscopyoxidative stressschizophrenia

Identifiers

PMID32899276
PMCPMC7565827
OpenAlexW3082204994

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.