Quantifying 3D Strain in Scaffold Implants for Regenerative Medicine.

Jeffrey N Clark, Saman Tavana, Agathe Heyraud, Francesca Tallia, Julian R Jones, Ulrich Hansen, Jonathan R T Jeffers

Abstract read

In one paragraph

Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

In Vivo Deformation and Strain Measurements in Human Bone Using Digital Volume Correlation (DVC) and 3T Clinical MRI.Materials (Basel, Switzerland) · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeffrey N ClarkDepartment of Mechanical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.ORCID 0000-0003-0118-3999

Saman TavanaDepartment of Mechanical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.ORCID 0000-0003-0008-7874

Agathe HeyraudDepartment of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

Francesca TalliaDepartment of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.ORCID 0000-0002-1866-6244

Julian R JonesDepartment of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.ORCID 0000-0002-2647-8024

Ulrich HansenDepartment of Mechanical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

Jonathan R T JeffersDepartment of Mechanical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.ORCID 0000-0001-8496-6889

Funding

Department of Health NIHR300013Engineering and Physical Sciences Research Council EP/N025059/1

6 · The paper itself

Abstract

Regenerative medicine solutions require thoughtful design to elicit the intended biological response. This includes the biomechanical stimulus to generate an appropriate strain in the scaffold and surrounding tissue to drive cell lineage to the desired tissue. To provide appropriate strain on a local level, new generations of scaffolds often involve anisotropic spatially graded mechanical properties that cannot be characterised with traditional materials testing equipment. Volumetric examination is possible with three-dimensional (3D) imaging, in situ loading and digital volume correlation (DVC). Micro-CT and DVC were utilised in this study on two sizes of 3D-printed inorganic/organic hybrid scaffolds (

Indexed as

biomaterialscartilage regenerationdigital volume correlationin situ mechanicsmicro-CTtissue regenerationX-ray computed tomography

Identifiers

PMID32899192

DOI10.3390/ma13173890

PMCPMC7504351

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.