ArticleMolecular metabolism2020
Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons.
Article in Molecular metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism.Nature metabolism · 2026Article
- Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons.Nature metabolism · 2026Article
- MASH-Associated T Cell Activation and Neuroinflammation: Evidence for a Hepatosystemic Immune Axis.Seminars in liver disease · 2026Review
- Cellular coding of ingestion in the caudal brainstem.bioRxiv : the preprint server for biology · 2026Article
- Brain Nutrient Sensing: A Unifying Framework.Annual review of physiology · 2026Review
- Brain amino acid sensing for organismal amino acid homeostasis.Open biology · 2025Review
- The role of GIPR in food intake control.Frontiers in endocrinology · 2025Review
- Central and peripheral neural circuits regulating glucose homeostasis.npj biomedical innovations · 2025Review
- Article
- Electrophysiological responses to appetitive and consummatory behavior in the rostral nucleus tractus solitarius in awake, unrestrained rats.bioRxiv : the preprint server for biology · 2024Article
- A brainstem to hypothalamic arcuate nucleus GABAergic circuit drives feeding.Current biology : CB · 2024Article
- Mice lacking ASIC2 and βENaC are protected from high-fat-diet-induced metabolic syndrome.Frontiers in endocrinology · 2024Article
- Article
- Protein appetite as an integrator in the obesity system: the protein leverage hypothesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Adrenergic modulation of melanocortin pathway by hunger signals.Nature communications · 2023Article
- Whey protein hydrolysates improve high-fat-diet-induced obesity by modulating the brain-peripheral axis of GLP-1 through inhibition of DPP-4 function in mice.European journal of nutrition · 2023Article
- Hindbrain circuits in the control of eating behaviour and energy balance.Nature metabolism · 2022Review
- The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond.IBRO neuroscience reports · 2022Review
- Integrative Hedonic and Homeostatic Food Intake Regulation by the Central Nervous System: Insights from Neuroimaging.Brain sciences · 2022Review
- Impacts of essential amino acids on energy balance.Molecular metabolism · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The nucleus of the solitary tract (NTS) is emerging as a major site of action for the appetite-suppressive effects of leading pharmacotherapies currently investigated to treat obesity. However, our understanding of how NTS neurons regulate appetite remains incomplete.
objectivesIn this study, we used NTS nutrient sensing as an entry point to characterize stimulus-defined neuronal ensembles engaged by the NTS to produce physiological satiety.
methodsWe combined histological analysis, neuroanatomical assessment using inducible viral tracing tools, and functional tests to characterize hindbrain-forebrain circuits engaged by NTS leucine sensing to suppress hunger.
resultsWe found that NTS detection of leucine engages NTS prolactin-releasing peptide (PrRP) neurons to inhibit AgRP neurons via a population of leptin receptor-expressing neurons in the dorsomedial hypothalamus. This circuit is necessary for the anorectic response to NTS leucine, the appetite-suppressive effect of high-protein diets, and the long-term control of energy balance.
conclusionsThese results extend the integrative capability of AgRP neurons to include brainstem nutrient sensing inputs.
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Registered trials
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