Evidence map›Paper›PMID 32898478›Full record

ArticleBiophysical journal2020

Dissecting Dynamic and Hydration Contributions to Sequence-Dependent DNA Minor Groove Recognition.

Van L T Ha, Noa Erlitzki, Abdelbasset A Farahat, Arvind Kumar, David W Boykin, Gregory M K Poon

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Van L T HaDepartment of Chemistry, Georgia State University, Atlanta, Georgia.
Noa ErlitzkiDepartment of Chemistry, Georgia State University, Atlanta, Georgia.
Abdelbasset A FarahatDepartment of Chemistry, Georgia State University, Atlanta, Georgia; Department of Pharmaceutical and Medicinal Chemistry, California Northstate University, Elk Grove, California.
Arvind KumarDepartment of Chemistry, Georgia State University, Atlanta, Georgia.
David W BoykinDepartment of Chemistry, Georgia State University, Atlanta, Georgia.
Gregory M K PoonDepartment of Chemistry, Georgia State University, Atlanta, Georgia; Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia. Electronic address: gpoon@gsu.edu.
Georgia State University · US

Funding

A cellular osmotic pressure sensorR21GM137160 · NIGMS · GEORGIA STATE UNIVERSITY · PI POON, GREGORY MAN KAI · 2020 to 2021
$428k
NIGMS NIH HHS R21 GM137160
6 · The paper itself

Abstract

Sequence selectivity is a critical attribute of DNA-binding ligands and underlines the need for detailed molecular descriptions of binding in representative sequence contexts. We investigated the binding and volumetric properties of DB1976, a model bis(benzimidazole)-selenophene diamidine compound with emerging therapeutic potential in acute myeloid leukemia, debilitating fibroses, and obesity-related liver dysfunction. To sample the scope of cognate DB1976 target sites, we evaluated three dodecameric duplexes spanning >10

Indexed as

DNAWaterBinding SitesLigandsMolecular Dynamics SimulationNucleic Acid ConformationDNALigandsWater

Identifiers

PMID32898478
PMCPMC7567977
OpenAlexW3080598886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.