ArticleClinical and translational medicine2020
Gut microbial clues to bipolar disorder: State-of-the-art review of current findings and future directions.
Article in Clinical and translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Gut microbiota remodeling and sensory-emotional functional disruption in adolescents with bipolar depression.Journal of translational medicine · 2025Trial
- A multi-omics analysis of gut bacteriome, virome, and serum metabolome in bipolar depression.Npj mental health research · 2026Article
- Can bacteria control the human brain?Communicative & integrative biology · 2026Review
- Vitamin B12 and Affective Disorders: A Focus on the Gut-Brain Axis.Alpha psychiatry · 2025Review
- The Gut Microbiome and Its Impact on Mood and Decision-Making: A Mechanistic and Therapeutic Review.Nutrients · 2025Review
- The emerging roles of microbiota-derived extracellular vesicles in psychiatric disorders.Frontiers in microbiology · 2024Review
- Characterization of gut microbiota profile in Iranian patients with bipolar disorder compared to healthy controls.Frontiers in cellular and infection microbiology · 2023Article
- Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression.Molecular psychiatry · 2022Article
- Obesity and the Brain.International journal of molecular sciences · 2022Review
- Role of the gut microbiome in three major psychiatric disorders.Psychological medicine · 2022Review
- A pilot exploration of multi-omics research of gut microbiome in major depressive disorders.Translational psychiatry · 2022Article
- Phage-mediated horizontal gene transfer and its implications for the human gut microbiome.Gastroenterology report · 2022Article
- Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence.Frontiers in pharmacology · 2022Review
- Impaired blood-brain barrier in the microbiota-gut-brain axis: Potential role of bipolar susceptibility gene TRANK1.Journal of cellular and molecular medicine · 2021Review
- New Evidence of Gut Microbiota Involvement in the Neuropathogenesis of Bipolar Depression byFrontiers in immunology · 2021Observational
- Gut microbial clues to bipolar disorder: State-of-the-art review of current findings and future directions.Clinical and translational medicine · 2020Article
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Authors and funding
14 authors.
Funding
Abstract
Trillions of microorganisms inhabiting in the human gut play an essential role in maintaining physical and mental health. The connections between gut microbiome and neuropsychiatric diseases have been recently identified. The pathogenesis of bipolar disorder, a spectrum of diseases manifesting with mood and energy fluctuations, also seems to be involved in the bidirectional modulation of the microbiome-gut-brain (MGB) axis. In this review, we briefly introduce the concept of MGB axis, and then focus on the previous findings in human studies associated with bipolar disorder. These studies provided preliminary evidences on the gut microbial alterations in bipolar disorder. Limitations in these studies and future directions in this research field, such as fecal microbiome transplantation and microbiome-targeted therapy, were discussed. A research framework linking gut microbiome to determinants and health-related outcomes in BD was also proposed. Better characterizing and understanding of gut microbial biosignatures in bipolar patients contribute to clarify the etiology of this intractable disease and pave the new way for treatment innovation.
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Registered trials
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