Evidence map›Paper›PMID 32897936›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2020

Brief Report: Time to Repeat Viral Load Testing Among Unsuppressed Adolescents and Young Adults Living With HIV in Kenya.

Cyrus Mugo, Katherine S Wilson, Alvin Onyango, Irene N Njuguna, Caren W Mburu, Barbra A Richardson, Laura Oyiengo, Irene Inwani, Grace John-Stewart, Dalton C Wamalwa and 1 more

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cyrus MugoDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Katherine S WilsonGlobal Health, University of Washington, Seattle, WA.
Alvin OnyangoDepartment of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Irene N NjugunaGlobal Health, University of Washington, Seattle, WA.
Caren W MburuGlobal Health, University of Washington, Seattle, WA.
Barbra A RichardsonGlobal Health, University of Washington, Seattle, WA.
Laura OyiengoNational AIDS and STI Control Programme, Ministry of Health, Nairobi, Kenya.
Irene InwaniDepartment of Pediatrics, Kenyatta National Hospital, Nairobi, Kenya; and.
Grace John-StewartDepartments of Epidemiology; and.
Dalton C WamalwaDepartment of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Pamela K KohlerGlobal Health, University of Washington, Seattle, WA.

Funding

Women and HIV: Translation of Research into Practice-WLHIV Post-Graduate Research FellowshipD43TW009783 · FIC · UNIVERSITY OF WASHINGTON · PI Elizabeth Anne BUKUSI, CAREY FARQUHAR · 2015 to 2026
$4.1M
Transitioning from Pediatric to Adult HIV Care in Kenya Administrative SupplementR01HD089850 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2016 to 2020
$2.3M
Simulated Patient Encounters to Promote Early Detection and Engagement in HIV Care for AdolescentsR01HD085807 · NICHD · UNIVERSITY OF WASHINGTON · PI KOHLER, PAMELA · 2015 to 2019
$2.1M
FIC NIH HHS D43 TW009783NICHD NIH HHS R01 HD085807NICHD NIH HHS R01 HD089850
6 · The paper itself

Abstract

backgroundRepeat HIV viral load (VL) testing is required after unsuppressed VL to confirm treatment failure. We assessed proportion of adolescents and young adults living with HIV (AYALHIV) in Kenya with a confirmatory VL test and time to repeat testing.

designA retrospective analysis of longitudinal data abstracted from Kenya's national VL database.

methodsVL data for AYALHIV who were 10-24 year old between April 2017 and May 2019 were abstracted from 117 HIV care clinics. Records were eligible if at least one VL test was performed ≥6 months after antiretroviral therapy (ART) initiation. The proportion of unsuppressed AYALHIV (≥1000 copies/mL) and time in months between first unsuppressed VL and repeat VL was determined.

resultsWe abstracted 40,928 VL records for 23,969 AYALHIV; of whom, 17,092 (71%) were eligible for this analysis. Of these, 12,122 (71%) were women, median age of 19 years [interquartile range (IQR): 13-23], and median ART duration of 38 months (IQR: 16-76). Among eligible AYALHIV, 4010 (23%) had an unsuppressed VL at first eligible measurement. Only 316 (8%) of the unsuppressed AYALHIV had a repeat VL within 3 months and 1176 (29%) within 6 months. Among 2311 virally unsuppressed AYALHIV with a repeat VL, the median time between the first and the repeat VL was 6 months (IQR: 4-8), with 1330 (58%) having confirmed treatment failure.

conclusionsOne-quarter of AYALHIV on ART had unsuppressed VL, with less than a third receiving a repeat VL within 6 months. Strategies to improve VL testing practices are needed to improve AYALHIV's outcomes.

Indexed as

Viral LoadAdolescentAge FactorsAnti-HIV AgentsChildFemaleHIV InfectionsHumansKenyaMaleRetrospective StudiesTime FactorsTreatment FailureYoung AdultAnti-HIV Agents

Identifiers

PMID32897936
PMCPMC8559766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.