ArticleThe Journal of clinical investigation2020
Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor.
Article in The Journal of clinical investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Second primary cancers following hematologic malignancies: Epidemiology, pathobiology and clinical management.Human vaccines & immunotherapeutics · 2026Review
- Divergent biology and outcomes of somatic transformations in germ cell tumors.The oncologist · 2026Article
- A Rare Case of Seminoma in an Elderly Patient With Suspected Lynch Syndrome.Clinical case reports · 2026Article
- Primary Extramedullary Acute Promyelocytic Leukemia Presenting as Cauda Equina Syndrome: A Rare Case Report and Diagnostic Challenge.Clinical case reports · 2026Article
- Cooccurrence of myelodysplastic neoplasm and myeloid sarcoma with background mediastinal germ cell tumor: an autopsy case.Journal of clinical and experimental hematopathology : JCEH · 2026Article
- A Polyomavirus-Positive Merkel Cell Carcinoma Mouse Model Supports a Unified Origin for Somatic and Germ Cell Cancers.Cancers · 2025Article
- Case Report: A rare case of synchronous ovarian mixed germ cell tumor and mast cell leukemia in a pediatric patient.Frontiers in oncology · 2025Article
- The New Tumour Biomarker miRNA-371-3p Influences Cisplatin Sensitivity of Testicular Germ Cell Tumour Cell Lines.Journal of cellular and molecular medicine · 2024Article
- Article
- The clonal hydra: neoantigen-specific T-cell response in germ cell tumors.Haematologica · 2024Article
- Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues.Cancer discovery · 2024Article
- Clinical and prognostic features of Langerhans cell histiocytosis in adults.Cancer science · 2023Article
- Severe graft-versus-host disease post allogeneic hematopoietic stem cell transplantation due to loss of HLA heterozygosity in recipient lymphocytes after full graft rejection.Cancer innovation · 2023Article
- Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Primary Mediastinal Germ Cell Tumors: A Thorough Literature Review.Biomedicines · 2023Review
- Malignant histiocytosis associated with mediastinal germ cell tumor: A case report.World journal of clinical cases · 2022Article
- Mediastinal germ cell tumours: where we are and where we are going-a narrative review.Mediastinum (Hong Kong, China) · 2022Review
- Acute Mast Cell Leukemia Preceded by Malignant Mediastinal Germ Cell Tumor: A Case Report and Literature Review.Cancer management and research · 2022Article
- Genomic features of mediastinal germ cell tumors: a narrative review.Mediastinum (Hong Kong, China) · 2022Review
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27 authors at 4 institutions in 2 countries.
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Abstract
Germ cell tumors (GCTs) are the most common cancer in men between the ages of 15 and 40. Although most patients are cured, those with disease arising in the mediastinum have distinctly poor outcomes. One in every 17 patients with primary mediastinal nonseminomatous GCTs develop an incurable hematologic malignancy and prior data intriguingly suggest a clonal relationship exists between hematologic malignancies and GCTs in these cases. To date, however, the precise clonal relationship between GCTs and the diverse additional somatic malignancies arising in such individuals have not been determined. Here, we traced the clonal evolution and characterized the genetic features of each neoplasm from a cohort of 15 patients with GCTs and associated hematologic malignancies. We discovered that GCTs and hematologic malignancies developing in such individuals evolved from a common shared precursor, nearly all of which harbored allelically imbalanced p53 and/or RAS pathway mutations. Hematologic malignancies arising in this setting genetically resembled mediastinal GCTs rather than de novo myeloid neoplasms. Our findings argue that this scenario represents a unique clinical syndrome, distinct from de novo GCTs or hematologic malignancies, initiated by an ancestral precursor that gives rise to the parallel evolution of GCTs and blood cancers in these patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.