ArticleEndocrine2021
Correlation between TSH levels and quality of life among subjects with well-controlled primary hypothyroidism.
Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Local symptoms of Hashimoto's thyroiditis: A systematic review.Frontiers in endocrinology · 2022Pooled it
- Quality of life in hypothyroid subjects treated with levothyroxine: a cross-sectional study.Thyroid research · 2026Article
- Psychometric properties of the thyroid-specific quality of life questionnaire ThyPRO-39 in patients with hypothyroidism.Journal of family medicine and primary care · 2026Article
- Acceptance of disease as a mediator between social support and quality of life in women with Hashimoto's disease-a pilot study.Scientific reports · 2025Article
- Glutathione Peroxidase and Selenoprotein P Evaluation in Well-Being Assessment After Total Thyroidectomy.International journal of molecular sciences · 2025Article
- Clinical thyroidology: beyond the 1970s' TSH-T4 Paradigm.Frontiers in endocrinology · 2025Review
- Characteristics, Physiopathology and Management of Dyslipidemias in Pregnancy: A Narrative Review.Nutrients · 2024Review
- ThyPRO-IR: Translation and Linguistic Validation of the Persian Version of Thyroid-Specific Quality of Life (QoL) Patient-Reported Outcome (PRO) Questionnaire for Benign Thyroid Disorders.International journal of endocrinology and metabolism · 2024Article
- Screening factors affecting proper levothyroxine therapy among patients with primary hypothyroidism: a cross-sectional study.Journal of medicine and life · 2024Observational
- Quality of life, social support, and adherence in female patients with thyroid disorders.BMC women's health · 2023Article
- Severity of hypothyroidism is inversely associated with impaired quality of life in patients referred to an endocrine clinic.Thyroid research · 2023Article
- Assessment of Quality of Life Among Patients With Primary Hypothyroidism: A Case-Control Study.Cureus · 2022Article
- Hypothyroidism and Depression: A Narrative Review.Cureus · 2022Review
- Hypothyroidism.Nature reviews. Disease primers · 2022Review
- Relatively Lower FT3 Levels Are Associated with Impaired Quality of Life in Levothyroxine-Treated Patients with Hashimoto Thyroiditis.International journal of endocrinology · 2022Article
- Evaluating health outcomes in the treatment of hypothyroidism.Frontiers in endocrinology · 2022Review
- What Is the Quality of Life in Patients Treated with Levothyroxine for Hypothyroidism and How Are We Measuring It? A Critical, Narrative Review.Journal of clinical medicine · 2021Review
- Health-Related Quality of Life in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control Study.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt has been suggested that increasing levothyroxine dose to lower TSH levels within the normal laboratory range might be a therapeutic option for patients with apparently well-controlled primary hypothyroidism who are dissatisfied with their treatment and complain of physical or psychological symptoms. This study assessed whether there is a relationship between TSH levels and health-related quality of life (HRQoL) among subjects with adequately treated hypothyroidism.
methodsHRQoL was measured with the specific thyroid disease ThyPRO-39 questionnaire in 218 consecutive patients with primary hypothyroidism of any cause attending an Endocrinology Department in a single center. Patients had TSH values within the normal laboratory range on a blood test performed not before than 6 weeks prior to study participation, but they were not aware of their lab results. The association between TSH values and the different ThyPRO-39 scales was analyzed by means of multiple regression models, both linear and additive, in which, in addition to TSH, a wide set of clinical and sociodemographic variables potentially related to HRQoL were also considered.
resultsTSH levels and the use of anxiolytic and antidepressant drugs were the only variables that showed a positive linear correlation with the ThyPRO-39 composite scale in the multivariate regression analysis, indicating greater impairment in HRQoL with increasing TSH values. TSH was also independently correlated to scores of scales dealing on tiredness and emotional susceptibility.
conclusionsIn patients with primary hypothyroidism, higher TSH values, even within the normal reference range, are associated with greater deterioration of HRQoL.
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