Evidence map›Paper›PMID 32897512›Full record

ArticleCellular and molecular neurobiology2022

Long Noncoding RNA KCNQ1OT1 Confers Gliomas Resistance to Temozolomide and Enhances Cell Growth by Retrieving PIM1 From miR-761.

Wei Wang, Shuai Han, Wei Gao, Yuan Feng, Kunhang Li, Di Wu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. METTL3-mediated mEpigenetics · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wei WangDepartment of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.ORCID http://orcid.org/0000-0002-8359-7679
Shuai HanDepartment of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.ORCID http://orcid.org/0000-0002-0398-2877
Wei GaoDepartment of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.ORCID http://orcid.org/0000-0003-1141-1182
Yuan FengDepartment of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.ORCID http://orcid.org/0000-0003-1033-1367
Kunhang LiDepartment of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.ORCID http://orcid.org/0000-0001-5556-1049
Di WuDepartment of Tumor Biotherapy and Cancer Research, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China. windy_wu0802@163.com.ORCID http://orcid.org/0000-0002-2594-1072
First Hospital of China Medical University · CNLiaoning Cancer Hospital & Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many studies have found that the dysregulation of long noncoding RNA (lncRNA) contributed to cancer initiation, progression, and recurrence via multiple signaling pathways. However, the underlying mechanisms of lncRNA in temozolomide (TMZ)-resistant gliomas were not well understood, hindering the improvement of TMZ-based therapies. The present study demonstrated that the lncRNA KCNQ1OT1 increased in TMZ-resistant glioma cells compared to the TMZ-sensitive cells. The introduction of KCNQ1OT1 promoted cell viability, clonogenicity, and rhodamine 123 efflux while hampering TMZ-induced apoptosis. Moreover, KCNQ1OT1 directly sponged miR-761, which decreased in TMZ-resistant sublines. The overexpression of miR-761 attenuated cell viability and clonogenicity, while triggering apoptosis and rhodamine 123 accumulation post-TMZ exposure, leading to a response to TMZ. The interaction between miR-761 and 3'-untranslated region of PIM1 attenuated PIM1-mediated signaling cascades. Furthermore, the knockdown of KCNQ1OT1 augmented the TMZ-induced tumor regression in TMZ-resistant U251 mouse models. Briefly, the present study evaluated that KCNQ1OT1 conferred TMZ resistance by releasing PIM1 expression from miR-761, resulting in the upregulation of PIM-mediated MDR1, c-Myc, and Survivin. The present findings demonstrated that the interplay of KCNQ1OT1: miR-761: PIM1 regulated chemoresistance in gliomas and provided a promising therapeutic target for TMZ-resistant glioma patients.

Indexed as

Drug Resistance, NeoplasmGliomaMicroRNAsProto-Oncogene Proteins c-pim-1RNA, Long NoncodingTemozolomideAnimalsAntineoplastic Agents, AlkylatingApoptosisCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMicePotassium Channels, Voltage-GatedAntineoplastic Agents, AlkylatingKCNQ1OT1 long non-coding RNA, humanmicroRNA761 microRNA, humanMicroRNAsPIM1 protein, humanPotassium Channels, Voltage-GatedProto-Oncogene Proteins c-pim-1RNA, Long NoncodingTemozolomideGliomaGrowthKCNQ1OT1miR-761PIM1Temozolomide resistance

Identifiers

PMID32897512
PMCPMC11441228
OpenAlexW3084029594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.