Evidence map›Paper›PMID 32897203›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2020

[Endoplasmic reticulum stress enhances tumor necrosis factor-

Hong Gao, Nan Wen, Xuesong Xu, Guoqing Hong, Xing Lai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021
    Article
  4. Strategies for Biomaterial-Based Spinal Cord Injury RepairFrontiers in bioengineering and biotechnology · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hong GaoDepartment of Hepatobiliary Surgery, Chongqing Fourth People's Hospital, Chongqing 400014, China.
Nan WenWest China School of Medicine, Sichuan University, Chengdu 610041, China.
Xuesong XuDepartment of Hepatobiliary Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Guoqing HongDepartment of Hepatobiliary Surgery, People's Hospital of Tongnan District, Chongqing 402660, China.
Xing LaiDepartment of Hepatobiliary Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the role of endoplasmic reticulum (ER)-stress of Kupffer cells (KCs) and KCs-derived tumor necrosis factor-

methodsSixty male SD rats were randomized into control group, model group, ER- stress group, depletion group and KCs block group (

resultsCompared with the rats in the control group, the rats in the model group had significantly increased ALT and AST levels, Sirius red staining-positive area, and Desmin-positive cells (activated HSCs) (

conclusionsER stress of KCs promotes the transformation of KCs towards M1 phenotype and increases the expression of TNF-

Indexed as

Endoplasmic Reticulum StressHepatic Stellate CellsKupffer CellsAnimalsApoptosisCaspase 8MaleRatsRats, Sprague-DawleyTumor Necrosis Factor-alphaCasp8 protein, ratCaspase 8Tumor Necrosis Factor-alphahepatic fibrosishepatic stellate cellsKupffer cellTNF-α

Identifiers

PMID32897203
PMCPMC7277312
OpenAlexW3036309302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.