ArticleDevelopmental psychobiology2021
Maltreatment exposure across childhood and low-grade inflammation: Considerations of exposure type, timing, and sex differences.
Article in Developmental psychobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Sensitive periods to social adversity in immune and metabolic development: A systematic review.Psychoneuroendocrinology · 2025Pooled it
- Associations of childhood maltreatment types and timing with oxidative stress in formerly out-of-home placed young adults.European journal of psychotraumatology · 2026Article
- Diagnosis of depression in adolescence signals improved inflammatory health in adulthood: Results from a nationally representative longitudinal study.Brain, behavior, and immunity · 2026Article
- Inflammation-related aberrations in beta and gamma oscillatory dynamics serving attention processing in typically developing youth.Brain communications · 2026Article
- Chronic radon exposure is associated with developmental alterations to neural and behavioral indices of cognitive control.NeuroImage · 2025Article
- The Effects of Childhood Abuse on Emerging Adulthood Inflammation: Investigating Protective Characteristics.Child maltreatment · 2025Article
- Sexual Minority Identity and Physical Illnesses: Role of Life-Course Victimization and Gender Differences.American journal of preventive medicine · 2025Article
- Trauma-Based Sexually Dimorphic Changes in the Connectome and Its Association with Central Sensitization Syndromes-A Systematic Review.Brain sciences · 2024Review
- Interpersonal violence exposure and inflammation during adolescence and young adulthood.Psychoneuroendocrinology · 2024Article
- Childhood Maltreatment and Body Mass Index in Older Adults With Chronic Illness.CJC pediatric and congenital heart disease · 2024Article
- Neurotoxic effects of home radon exposure on oscillatory dynamics serving attentional orienting in children and adolescents.NeuroImage · 2024Article
- Exposure to parental depression in adolescence and proinflammatory phenotypes 20 years later.Brain, behavior, and immunity · 2024Article
- Inflammatory burden of adolescents with childhood maltreatment: results from baseline data of a school cohort.European child & adolescent psychiatry · 2024Article
- Do trait-level emotion regulation strategies moderate associations between retrospective reports of childhood trauma and prospective changes in systemic inflammation?Stress and health : journal of the International Society for the Investigation of Stress · 2023Article
- Cumulative life-course victimization and inflammation in a U.S. national sample: Comparing intersections based on sexual orientation, gender, race/ethnicity, and education.Preventive medicine · 2023Article
- Gender- and age-specific associations of childhood maltreatment with peripheral serum inflammatory cytokines in middle school students.Frontiers in immunology · 2023Article
- Chronic Home Radon Exposure Is Associated with Higher Inflammatory Biomarker Concentrations in Children and Adolescents.International journal of environmental research and public health · 2022Article
- Psychobiological foundations of coping and emotion regulation: Links to maltreatment and depression in a racially diverse, economically disadvantaged sample of adolescent girls.Psychoneuroendocrinology · 2022Article
- Associations Between Child Maltreatment, Inflammation, and Comorbid Metabolic Syndrome to Depressed Mood in a Multiethnic Urban Population: The HELIUS Study.Frontiers in psychology · 2022Article
- Abuse in Childhood and Cardiometabolic Health in Early Adulthood: Evidence From the Avon Longitudinal Study of Parents and Children.Journal of the American Heart Association · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Links between child maltreatment and low-grade inflammation in adulthood are well documented, but these studies often rely on adults to report retrospectively on experiences of childhood abuse. Furthermore, these findings raise questions about whether exposure to childhood maltreatment needs time to "incubate," only giving rise to nonresolving inflammation in adulthood, or whether heightened inflammation may be observable in childhood, closer in time to the maltreatment exposure. The present study examined this question in a sample of 155 low-income children (ages 8-12), half of whom had been exposed to maltreatment. Trained coders evaluated case reports to classify maltreatment based on timing and exposure type. Blood samples from children assessed C-reactive protein and cytokines, which were used to form a composite of low-grade inflammation. Analyses revealed a marginally significant Maltreatment Exposure × Sex interaction, which suggested that maltreatment exposure was associated with higher inflammation for girls but not boys. Additionally, analyses focused on the accumulation of maltreatment experiences (through multiple forms of maltreatment or across multiple time points) revealed that girls with greater diversity in their maltreatment experiences and those who experienced maltreatment at multiple time points were at greatest risk. Finally, examination of timing of first onset of maltreatment suggested that girls whose exposures occurred before the age of 5 had the highest low-grade inflammation. These findings add new evidence linking maltreatment to inflammation in childhood, which could increase the risk for mental and physical health problems across the lifespan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.