ArticleCell calcium2020
Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels.
Open access · greenAbstract read
In one paragraph
Article in Cell calcium, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 106 citations in OpenAlex.
- Mechanistic insights into Orai dynamics during pore opening.Channels (Austin, Tex.) · 2026Review
- Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases.Channels (Austin, Tex.) · 2026Review
- STIM-Orai signaling in neurons: integrating calcium dynamics and synaptic plasticity.Cell communication and signaling : CCS · 2026Review
- Breaking the Calcium Overload Cycle in Acute Pancreatitis: Emerging Pharmacological Strategies.Digestive diseases and sciences · 2026Review
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Functional model for amelogenesis: polarization and pH sensitivity of calcium uptake in ameloblast-derived HAT-7 cells.Calcified tissue international · 2026Article
- STIM/Orai-Mediated Store-Operated CaCells · 2026Review
- Microglial Adaptations to Chronic Nicotine in the Cerebellum: Proteomic Evidence for Neuroimmune Vulnerability.Journal of proteome research · 2026Article
- Orai1- and STIM1-mediated calcium signaling controls PD-L1 expression and modulates antitumor immunity in oral cancer.The journal of physiological sciences : JPS · 2026Article
- Molecular Mechanisms and Targeted Intervention Strategies of Calcium Overload in Ischemic Stroke.International journal of molecular sciences · 2026Review
- Targeted therapeutics for pancreatitis.Frontiers in physiology · 2026Review
- Context-dependent dysregulation of store-operated calcium channels in head and neck squamous cell carcinoma.PloS one · 2026Article
- Orai1 is Required for Osteogenic Differentiation on Nanoparticulate Mineralized Collagen Glycosaminoglycan Materials.Macromolecular bioscience · 2025Article
- Neutrophil store-operated CaJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2025Article
- Endothelial CYB5R3 couples store-operated calcium entry to TRPV2 activation and vascular fitness.bioRxiv : the preprint server for biology · 2025Article
- Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025Review
- Relevance of STIM/Orai Calcium Entry System Hyperactivation in Human Prostate Contractility in Benign Prostate Hyperplasia.International journal of molecular sciences · 2025Article
- Resting CaCellular and molecular life sciences : CMLS · 2025Article
- CaBiomedicines · 2025Review
- Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Xuexin ZhangDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr. Hershey, PA, 17033 USA. Electronic address: xxz28@psu.edu.
Ping XinDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr. Hershey, PA, 17033 USA.
Ryan E YoastDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr. Hershey, PA, 17033 USA.
Scott M EmrichDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr. Hershey, PA, 17033 USA.
Martin T JohnsonDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr. Hershey, PA, 17033 USA.
Trayambak PathakDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr. Hershey, PA, 17033 USA.
J Cory BensonDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr. Hershey, PA, 17033 USA.
Iman AzimiSchool of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart 7001, Tasmania, Australia.
Donald L GillDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr. Hershey, PA, 17033 USA.
Gregory R MonteithSchool of Pharmacy, The University of Queensland, Brisbane 4072, Queensland, Australia.
Mohamed TrebakDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr. Hershey, PA, 17033 USA; Penn State Cancer Institute, The Pennsylvania State University College of Medicine, 500 University Dr. Hershey, PA, 17033 USA. Electronic address: mtrebak@psu.edu.
Pennsylvania State University · USThe University of Queensland · AUUniversity of Tasmania · AU
Funding
Ca2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4MUnderstanding Store-Operated Calcium Signal TransductionR35GM131916 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2019 to 2023
$2.9MThe Mitochondrial Sodium/Calcium Exchanger (NCLX) in Airway Smooth Muscle Remodeling during AsthmaF30HL147489 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI JOHNSON, MARTIN T · 2019 to 2022
$149kNHLBI NIH HHS F30 HL147489NHLBI NIH HHS R35 HL150778NIGMS NIH HHS R35 GM131916
Abstract
The ubiquitous Ca
Indexed as
AnilidesBenzamidesCalcium ChannelsHEK293 CellsHumansORAI1 ProteinORAI2 ProteinProtein IsoformsProtein MultimerizationPyrazolesThiadiazoles2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilideAnilidesBenzamidesCalcium ChannelsORAI1 ProteinORAI1 protein, humanORAI2 ProteinORAI2 protein, humanOrai3 protein, humanProtein IsoformsPyrazolesThiadiazolesCalcium signalingCRAC channelsORAI1/2/3pHPharmacological compounds
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.