Evidence map›Paper›PMID 32896540›Full record

ArticleJournal of neuroscience methods2020

Novel proton exchange rate MRI presents unique contrast in brains of ischemic stroke patients.

Zhenxiong Wang, Mehran Shaghaghi, Shun Zhang, Guiling Zhang, Yiran Zhou, Di Wu, Zhuoli Zhang, Wenzhen Zhu, Kejia Cai

Abstract read
In one paragraph

Article in Journal of neuroscience methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  4. Article
  5. Article
  6. TowardBiosensors · 2022
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhenxiong WangDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Departments of Radiology, Department of Bioengineering, the Center for MR Research, University of Illinois at Chicago, Chicago, USA.
Mehran ShaghaghiDepartments of Radiology, Department of Bioengineering, the Center for MR Research, University of Illinois at Chicago, Chicago, USA.
Shun ZhangDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Guiling ZhangDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yiran ZhouDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Di WuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhuoli ZhangDepartment of Radiology, Northwestern University, Chicago, USA.
Wenzhen ZhuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: zhuwenzhen8612@163.com.
Kejia CaiDepartments of Radiology, Department of Bioengineering, the Center for MR Research, University of Illinois at Chicago, Chicago, USA. Electronic address: kcai@uic.edu.

Funding

Deciphering molecular mechanisms that underlie brain endothelial cell dysfunction with APOE4R01AG061114 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Leon Maing Tai · 2019 to 2026
$4.7M
Targeting APOE modulated neurovascular dysfunctionR21AG053876 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TAI, LEON MAING · 2017 to 2018
$440k
Take pictures of short-lived ROS with endogenous contrast MRIR21EB023516 · NIBIB · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CAI, KEJIA · 2017 to 2018
$440k
NIA NIH HHS R01 AG061114NIA NIH HHS R21 AG053876NIBIB NIH HHS R21 EB023516
6 · The paper itself

Abstract

backgroundTo map and quantify the proton exchange rate (k NEW

methodThree sets of Z-spectra were acquired from seventeen ischemic stroke patients using a spin echo-echo planar imaging sequence with pre-saturation chemical exchange saturation transfer (CEST) pulse at B

resultsThe derived k COMPARISON WITH EXISTING METHOD(S): The k

conclusionsIn this preliminary translational research, the k

Indexed as

Brain IschemiaIschemic StrokeStrokeBrainHumansMagnetic Resonance ImagingProtonsProtonsChemical exchange saturation transfer (CEST)Omega plotProton exchange rate ()Stroke

Identifiers

PMID32896540
PMCPMC7606776

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.