ReviewBiological psychiatry2021
Adolescent Neurodevelopment and Vulnerability to Psychosis.
Review in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies.Frontiers in psychiatry · 2024Pooled it
- Pooled it
- Childhood premorbid adjustment as a marker for 20-year impairments in schizophrenia spectrum disorder: results from the OPUS study.European child & adolescent psychiatry · 2026Trial
- Trial
- Pharmacokinetics and safety of a new generic lurasidone: a phase I bioequivalence study in healthy Chinese subjects.Naunyn-Schmiedeberg's archives of pharmacology · 2024Trial
- Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.Molecular psychiatry · 2026Article
- How Intergenerational Injustice Impacts Young People's Mental Health: A Qualitative Study.Early intervention in psychiatry · 2026Article
- The correlations between psychotic symptoms and childhood maltreatment as well as sex differences in adolescents with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Polygenic risk meets early trauma: toward a neuropsychodevelopmental model of schizophrenia.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Childhood adversity and psychotic-like experiences in adolescence: Investigating a pathway via disrupted pubertal and grey matter development.JCPP advances · 2026Article
- Schizophrenia: from mechanism to therapy.Science China. Life sciences · 2026Review
- Neighborhood Characteristics and Psychosis Risk Across Development.Schizophrenia research · 2026Article
- Early-Age onset of psychotic spectrum symptoms is highly prevalent and associated with greater illness severity in schizophrenia spectrum disorders that develop later in life.Social psychiatry and psychiatric epidemiology · 2026Observational
- Paternal Broader Autism Phenotype and Adolescent Avoidant Attachment as Independent Predictors of Negative Symptoms in Early Psychosis.Brain and behavior · 2026Article
- Assessment of noninvasive quantification of [European journal of nuclear medicine and molecular imaging · 2026Article
- Self-Reported Psychosis Spectrum Symptoms Among Sexual and Gender Diverse Emerging Adults Screened for a Suicide Prevention Trial.Archives of sexual behavior · 2026Article
- Age-Related Effects of Cannabis and Cannabinoids on Brain and Behavior.Cannabis and cannabinoid research · 2026Review
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- Early Pubertal Development Is a Risk Factor for Psychotic-Like Experiences in Boys and Girls.Biological psychiatry global open science · 2026Article
- Neighborhood social fragmentation and cerebello-thalamo-cortical connectivity in youth at clinical high-risk for psychosis and healthy comparisons.Brain and environment · 2026Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Adolescence is characterized by significant changes in several domains, including brain structure and function, puberty, and social and environmental factors. Some of these changes serve to increase the likelihood of psychosis onset during this period, while others may buffer this risk. This review characterizes our current knowledge regarding the unique aspects of adolescence that may serve as risk factors for schizophrenia spectrum disorders. In addition, we provide potential future directions for research into adolescent-specific developmental mechanisms that impart vulnerability to psychosis and the possibility of interventions that capitalize on adolescents' unique characteristics. Specifically, we explore the ways in which gray and white matter develop throughout adolescence in typically developing youth as well as in those with psychosis spectrum disorders. We also discuss current views on the function that social support and demands, as well as role expectations, play in risk for psychosis. We further highlight the importance of considering biological factors such as puberty and hormonal changes as areas of unique vulnerability for adolescents. Finally, we discuss cannabis use as a factor that may have a unique impact during adolescent neurodevelopment, and subsequently potentially impact psychosis onset. Throughout, we include discussion of resilience factors that may provide unique opportunities for intervention during this dynamic life stage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.