ArticleACS sensors2020
Mass Transfer Limitations of Porous Silicon-Based Biosensors for Protein Detection.
Article in ACS sensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Lab-on-a-chip device with an integrated surface acoustic wave micromixer for enhanced porous silicon biosensor performance.RSC advances · 2026Article
- Optical and Electrochemical Biosensors Using Electrochemically Etched Porous Silicon.Biosensors · 2026Review
- Model-Driven Discovery of Highly Sensitive Nanocolumnar NiO Electrochemical Glucose Sensors.ACS engineering Au · 2026Article
- Sheet Protector Strategy for Western Blot to Reduce Antibody Consumption and Incubation Time.Biological procedures online · 2025Article
- Nanomaterial-enhanced biosensors for polycystic ovarian syndrome diagnosis and pathophysiological insights.Mikrochimica acta · 2025Review
- Can we still use the Michaelis-Menten model for enzymatic microneedle sensors?Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Porous Silicon on Paper: A Platform for Quantitative Rapid Diagnostic Tests.ACS applied materials & interfaces · 2025Article
- Bioinks and biofabrication techniques for biosensors development: A review.Materials today. Bio · 2024Review
- Design of a Porous Silicon Biosensor: Characterization, Modeling, and Application to the Indirect Detection of Bacteria.Biosensors · 2024Article
- Enhancing the performance of porous silicon biosensors: the interplay of nanostructure design and microfluidic integration.Microsystems & nanoengineering · 2024Article
- Dielectrophoresis: An Approach to Increase Sensitivity, Reduce Response Time and to Suppress Nonspecific Binding in Biosensors?Biosensors · 2022Review
- Designing Electrochemical Biosensing Platforms Using Layered Carbon-Stabilized Porous Silicon Nanostructures.ACS applied materials & interfaces · 2022Article
- Wafer-Scale Fabrication and Transfer of Porous Silicon Films as Flexible Nanomaterials for Sensing Application.Nanomaterials (Basel, Switzerland) · 2022Article
- Aptasensors versus immunosensors-Which will prevail?Engineering in life sciences · 2022Review
- Peptide-Based Capture of Chikungunya Virus E2 Protein Using Porous Silicon Biosensor.Sensors (Basel, Switzerland) · 2021Article
- Porous Silicon-Based Aptasensors: Toward Cancer Protein Biomarker Detection.ACS measurement science au · 2021Article
- Morlet Wavelet Filtering and Phase Analysis to Reduce the Limit of Detection for Thin Film Optical Biosensors.ACS sensors · 2021Article
- Nanoporous Gold for the Miniaturization of In Vivo Electrochemical Aptamer-Based Sensors.ACS sensors · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porous silicon (PSi) thin films have been widely studied for biosensing applications, enabling label-free optical detection of numerous targets. The large surface area of these biosensors has been commonly recognized as one of the main advantages of the PSi nanostructure. However, in practice, without application of signal amplification strategies, PSi-based biosensors suffer from limited sensitivity, compared to planar counterparts. Using a theoretical model, which describes the complex mass transport phenomena and reaction kinetics in these porous nanomaterials, we reveal that the interrelated effect of bulk and hindered diffusion is the main limiting factor of PSi-based biosensors. Thus, without significantly accelerating the mass transport to and within the nanostructure, the target capture performance of these biosensors would be comparable, regardless of the nature of the capture probe-target pair. We use our model to investigate the effect of various structural and biosensor characteristics on the capture performance of such biosensors and suggest rules of thumb for their optimization.
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