Evidence map›Paper›PMID 32896035›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2020

Relative and absolute cancer risks among Nordic kidney transplant recipients-a population-based study.

Henrik Benoni, Sandra Eloranta, Dag O Dahle, My H S Svensson, Arno Nordin, Jan Carstens, Geir Mjøen, Ilkka Helanterä, Vivan Hellström, Gunilla Enblad and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Evaluating cancer risk profiles in lung transplant recipients.Translational lung cancer research · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Previous Solid Organ Transplantation Influences Both Cancer Treatment and Survival Among Colorectal Cancer Patients.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  11. Incidence ofTransplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 4 countries.

Henrik BenoniDepartment of Surgery, Akademiska University Hospital, Uppsala, Sweden.ORCID 0000-0001-6479-2682
Sandra ElorantaClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Dag O DahleDepartment of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
My H S SvenssonDepartment of Nephrology, Aarhus University Hospital, Aarhus, Denmark.
Arno NordinTransplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, Finland.
Jan CarstensDepartment of Nephrology, Odense University Hospital, Odense, Denmark.
Geir MjøenDepartment of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Ilkka HelanteräTransplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-2954-2538
Vivan HellströmDepartment of Surgery, Akademiska University Hospital, Uppsala, Sweden.ORCID 0000-0002-2413-253X
Gunilla EnbladDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Eero PukkalaFinnish Cancer Registry - Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
Søren S SørensenDepartment of Nephrology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Marko LempinenTransplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, Finland.
Karin E SmedbyClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
University of Helsinki · FIOslo University Hospital · NOUppsala University Hospital · SEAkershus University Hospital · NOCopenhagen University Hospital · DKKarolinska Institutet · SEKarolinska University Hospital · SEOdense University Hospital · DKTampere University · FIUppsala University · SE

Funding

Janssen Pharmaceuticals 5-63/2015NovartisScandiaTransplantStrategic research program in epidemiology at Karolinska Institutet
6 · The paper itself

Abstract

Kidney transplant recipients (KTRs) have an increased cancer risk compared to the general population, but absolute risks that better reflect the clinical impact of cancer are seldom estimated. All KTRs in Sweden, Norway, Denmark, and Finland, with a first transplantation between 1995 and 2011, were identified through national registries. Post-transplantation cancer occurrence was assessed through linkage with cancer registries. We estimated standardized incidence ratios (SIR), absolute excess risks (AER), and cumulative incidence of cancer in the presence of competing risks. Overall, 12 984 KTRs developed 2215 cancers. The incidence rate of cancer overall was threefold increased (SIR 3.3, 95% confidence interval [CI]: 3.2-3.4). The AER of any cancer was 1560 cases (95% CI: 1468-1656) per 100 000 person-years. The highest AERs were observed for nonmelanoma skin cancer (838, 95% CI: 778-901), non-Hodgkin lymphoma (145, 95% CI: 119-174), lung cancer (126, 95% CI: 98.2-149), and kidney cancer (122, 95% CI: 98.0-149). The five- and ten-year cumulative incidence of any cancer was 8.1% (95% CI: 7.6-8.6%) and 16.8% (95% CI: 16.0-17.6%), respectively. Excess cancer risks were observed among Nordic KTRs for a wide range of cancers. Overall, 1 in 6 patients developed cancer within ten years, supporting extensive post-transplantation cancer vigilance.

Indexed as

Kidney TransplantationNeoplasmsCohort StudiesFinlandHumansIncidenceNorwayRegistriesRisk FactorsSwedencancerincidencemalignancyrisktransplantation

Identifiers

PMID32896035
PMCPMC7756726
OpenAlexW3084192295

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.