Evidence map›Paper›PMID 32895890›Full record

Trial reportAging clinical and experimental research2021

A double-blind randomized controlled trial of the efficacy of cognitive training delivered using two different methods in mild cognitive impairment in Parkinson's disease: preliminary report of benefits associated with the use of a computerized tool.

Sara Bernini, Silvia Panzarasa, Marica Barbieri, Elena Sinforiani, Silvana Quaglini, Cristina Tassorelli, Sara Bottiroli

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04111640 naunknown statusnot on this map

Evaluation of the Effectiveness of a Computerized Cognitive Training in the Early Stages of Neurodegenerative Diseases

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2017 to 2020Enrolled40ConditionsMild Cognitive ImpairmentArmsCoRe software, Control Group
NCT04889560 naunknown statusnot on this map

Home-based Cognitive Treatment of Early Stages of Cognitive Impairment in Neurodegenerative Diseases: Home CoRe

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2021 to 2024Enrolled40ConditionsCognitive ImpairmentArmsExperimental group, Control group
NCT06278818 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Neural and Clinical Correlates of Rehabilitation in Neurodegenerative Conditions

TypeinterventionalSponsorUniversity of PaviaRan2023 to 2026Enrolled110ConditionsMild Cognitive ImpairmentArmsCognitive Telerehabilitation, Control Condition
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Sara BerniniIRCCS Mondino Foundation, Pavia, Italy. sara.bernini@mondino.it.ORCID http://orcid.org/0000-0001-8615-0242
Silvia PanzarasaDept. of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.
Marica BarbieriIRCCS Mondino Foundation, Pavia, Italy.
Elena SinforianiIRCCS Mondino Foundation, Pavia, Italy.ORCID http://orcid.org/0000-0001-5512-6936
Silvana QuagliniDept. of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.ORCID http://orcid.org/0000-0002-4288-2561
Cristina TassorelliIRCCS Mondino Foundation, Pavia, Italy.ORCID http://orcid.org/0000-0003-1513-2113
Sara BottiroliIRCCS Mondino Foundation, Pavia, Italy.ORCID http://orcid.org/0000-0002-0151-3962
University of Pavia · ITFoundation Center · USGiustino Fortunato University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effectiveness of computer-based cognitive training (CCT) remains controversial, especially in older adults with neurodegenerative diseases.

aimsTo evaluate the efficacy of CCT in patients with Parkinson's disease and mild cognitive impairment (PD-MCI).

methodsIn this randomized controlled trial, 53 patients were randomized to receive CCT delivered by means of CoRe software, traditional paper-and-pencil cognitive training (PCT), or an unstructured activity intervention (CG). In each group, the intervention lasted 3 consecutive weeks (4 individual face-to-face sessions/week). Neuropsychological assessment was administered at baseline (T0) and post-intervention (T1). Outcome measures at T0 and T1 were compared within and between groups. The Montreal Overall Cognitive Assessment (MoCA) was taken as the primary outcome measure.

resultsUnlike the PCT group and the CG, the patients receiving CCT showed significant medium/large effect size improvements in MoCA performance, global cognition, executive functions, and attention/processing speed. No baseline individual/demographic variables were associated with greater gains from the intervention, although a negative correlation with baseline MoCA performance was found.

conclusionCCT proved effective in PD-MCI patients when compared with traditional PCT. Further follow-up assessments are being conducted to verify the retention of the gains and the potential ability of the tool to delay conversion to PD-dementia. Trial registration number (ClinicalTrials.gov): NCT04111640 (30th September 2019).

Indexed as

Cognition DisordersCognitive DysfunctionParkinson DiseaseAgedCognitionHumansNeuropsychological TestsComputer-based cognitive trainingMild cognitive impairmentMulti-domain stimulationNeurodegenerative diseaseParkinson’s diseaseRandomized controlled trial

Identifiers

PMID32895890
OpenAlexW3084304778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.