Evidence map›Paper›PMID 32895856›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022

Development, diagnostic performance, and interobserver agreement of a

René R Sevag Packard, C David Cooke, Kenneth F Van Train, John R Votaw, James W Sayre, Joel L Lazewatsky, Kelly M Champagne, Cesare Orlandi, Ernest V Garcia, Jamshid Maddahi

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07761728 (Comparative Evaluation of 18F-Flurpiridaz and 82Rb-Chloride PET Myocardial Perfusion Imaging), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07761728 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Comparative Evaluation of 18F-Flurpiridaz and 82Rb-Chloride PET Myocardial Perfusion Imaging: The FLARE (Flurpiridaz vs. Rubidium Evaluation) Trial

TypeobservationalSponsorUniversity of California, Los AngelesRan2025 to 2027Enrolled60ConditionsCoronary Artery Disease, Coronary Microvascular Disease
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Subendocardial quantification enhances coronary artery disease detection inEuropean journal of nuclear medicine and molecular imaging · 2025
    Trial
  2. Trial
  3. Trial
  4. Trial
  5. American journal of nuclear medicine and molecular imaging · 2026
    Review
  6. The clinical promise ofNature cardiovascular research · 2025
    Article
  7. Electrochemical impedance spectroscopy unmasks high-risk atherosclerotic features in human coronary artery disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  8. Article
  9. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2022: positron emission tomography, computed tomography, and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
  10. Rest/stress myocardial perfusion imaging by positron emission tomography withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  11. Progress ofAnnals of nuclear cardiology · 2023
    Review
  12. Automation in Nuclear Cardiology: Time for Flurpiridaz to Join the Club.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  13. Novel Tracers and Radionuclides in PET Imaging.Radiologic clinics of North America · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

René R Sevag PackardDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. rpackard@mednet.ucla.edu.
C David CookeDepartment of Radiology and Imaging Sciences, Emory University Hospital, Emory University School of Medicine, Atlanta, GA, USA.
Kenneth F Van TrainSyntermed, Inc., Atlanta, GA, USA.
John R VotawDepartment of Radiology and Imaging Sciences, Emory University Hospital, Emory University School of Medicine, Atlanta, GA, USA.
James W SayreDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Joel L LazewatskyLantheus Medical Imaging, North Billerica, MA, USA.
Kelly M ChampagneSyntermed, Inc., Atlanta, GA, USA.
Cesare OrlandiLantheus Medical Imaging, North Billerica, MA, USA.
Ernest V GarciaDepartment of Radiology and Imaging Sciences, Emory University Hospital, Emory University School of Medicine, Atlanta, GA, USA.
Jamshid MaddahiDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Funding

Myocardial blood flow quantitation with the novel PET F-18 Fluripidaz imaging tracerR44HL123069 · NHLBI · SYNTERMED, INC, · PI MADDAHI, JAMSHID, VAN TRAIN, KENNETH · 2016 to 2017
$999k
Myocardial blood flow quantitation with the novel F-18 Flurpiridaz PET imaging trR43HL123069 · NHLBI · SYNTERMED, INC, · PI MADDAHI, JAMSHID, VAN TRAIN, KENNETH · 2014 to 2014
$165k
Integrating 3-D Intravascular Sensors with Fractional Flow Reserve for Lipid-Rich PlaquesI01BX004558 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI PACKARD, RENE R.S. · 2020 to 2023
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BLRD VA I01 BX004558NHLBI NIH HHS R43 HL123069NHLBI NIH HHS R44 HL123069
6 · The paper itself

Abstract

backgroundComputerized methodologies standardize the myocardial perfusion imaging (MPI) interpretation process.

methodsTo develop an automated relative perfusion quantitation approach for

resultsBoth approaches yielded comparable accuracies for the detection of global CAD, reaching 71% and 72% by visual reads, and 72% and 68% by automated relative quantitation, when using CAD ≥ 70% or ≥ 50% stenosis for significance, respectively. Similar results were observed when analyzing individual coronary territories. In both pharmacological and exercise stress, automated relative quantitation demonstrated significantly more interobserver agreement than visual reads.

conclusionsOur automated method of

Indexed as

Coronary Artery DiseaseMyocardial Perfusion ImagingPyridazinesHumansObserver VariationPerfusionPositron-Emission TomographyTomography, Emission-Computed, Single-PhotonPyridazinesautomated relative quantitationdiagnostic performanceFlurpiridazinterobserver variabilityPET MPI

Identifiers

PMID32895856
PMCPMC7936994

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.