Observational studyCardiovascular and interventional radiology2021
Comparison Between CBCT and Fusion PET/CT-CBCT Guidance for Lung Biopsies.
Observational study in Cardiovascular and interventional radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Diagnostic Efficacy of PET/CT-Aided versus Conventional CT-guided Lung Biopsy: A Systematic Review and Meta-AnalysisCurrent medical imaging · 2025Pooled it
- Clinical potential of computed tomography-guided coaxial needle sequence puncture with suture-anchored needle guidance and coupled needle retraction-and-advancement technique biopsy of pulmonary nodules.Frontiers in oncology · 2026Trial
- Utility of preoperative [¹⁸F]FDG PET/CT for CT-guided biopsy planning of large tumors: target adjustment and malignant yield with hotspot targeting.Annals of nuclear medicine · 2026Article
- Advances in the application of different imaging techniques in percutaneous lung biopsy.Frontiers in medicine · 2026Review
- Dual-Layer Spectral CT with Electron Density in Bone Marrow Edema Diagnosis: A Valid Alternative to MRI?Journal of clinical medicine · 2025Article
- Computed-Tomography-Guided Lung Biopsy: A Practice-Oriented Document on Techniques and Principles and a Review of the Literature.Diagnostics (Basel, Switzerland) · 2024Review
- Histology profiling of lung tumors: tru-cut versus full-core system for CT-guided biopsies.La Radiologia medica · 2024Article
- PET/CT-aided biopsy of lung lesions enhances diagnostic efficacy, especially for lesions >3cm.Frontiers in oncology · 2024Article
- Dual-Layer Spectral CT as Innovative Imaging Guidance in Lung Biopsies: Could Color-Coded Z-Effective Images Allow More Diagnostic Samplings and Biomarkers Information?Journal of clinical medicine · 2023Article
- Dual-layer spectral CT fusion imaging for lung biopsies: more accurate targets, diagnostic samplings, and biomarker information?European radiology experimental · 2022Article
- Improving CT-guided transthoracic biopsy diagnostic yield of lung masses using intraprocedural CT and prior PET/CT fusion imaging.BMC pulmonary medicine · 2022Article
- Interventional Radiology ex-machina: impact of Artificial Intelligence on practice.La Radiologia medica · 2021Review
- Role of Fusion Imaging in Image-Guided Thermal Ablations.Diagnostics (Basel, Switzerland) · 2021Review
- Robotics in Interventional Radiology: Review of Current and Future Applications.Technology in cancer research & treatmentReview
- Could Maximum SUV be Used as Imaging Guidance in Large Lung Lesions Biopsies? Double Sampling Under PET-CT/XperGuide Fusion Imaging in Inhomogeneous Lung Uptaking Lesions to Show That it can Make a Difference.Technology in cancer research & treatmentArticle
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo establish the feasibility of performing percutaneous biopsy of lung lesions guided by fusion PET/CT-CBCT and to evaluate whether the metabolic information provided by a prior PET/CT scan add incremental benefits for diagnosis.
methodsWe retrospectively reviewed data from 180 patients who underwent CBCT-guided lung biopsy (group 1-90 cases) or PET/CT-CBCT fusion-guided lung biopsy (group 2-90 cases). Technical and clinical success was calculated. We also evaluated the agreement between biopsy and definitive histology and the possibility to carrying out immunehistochemical and molecular biology analyses.
resultsTechnical success was achieved in 84/90 (93.3%) cases for group 1 and 89/90 (98.9%) for group 2 cases (p 0.054). Clinical success was achieved in 80/94 (95.2%) cases for group 1 and 88/89 (98.9%) cases for group 2. Sensitivity, specificity, positive and negative predictive values and accuracy rate were, respectively, 94.5%, 100.0%, 100.0%, 73.3% and 95.2% for group 1 and 98.6%, 100.0%, 100.0%, 94.4% and 98.9% for group 2 (p 0.167). Agreement between biopsy and definitive histology was reached in 85.7% for group 1 and in 96.2% for group 2 (p 0.211). Immunohistochemical and molecular biology investigations were possible in 66.7% for group 1 and in 77.0% for group 2 (p 0.297). No major complication occurred.
conclusionsPET/CT-CBCT-guided lung biopsy is a feasible technique. In our retrospective case series, we found a higher clinical success rate, but no statistical difference was found.
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