Evidence map›Paper›PMID 32895729›Full record

SynthesisSocial psychiatry and psychiatric epidemiology2020

Prenatal tobacco use and the risk of mood disorders in offspring: a systematic review and meta-analysis.

Bereket Duko, Getinet Ayano, Gavin Pereira, Kim Betts, Rosa Alati

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Social psychiatry and psychiatric epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Bereket DukoSchool of Public Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia. b.adema@postgrad.curtin.edu.au.ORCID http://orcid.org/0000-0002-4419-0016
Getinet AyanoSchool of Public Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Gavin PereiraSchool of Public Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Kim BettsSchool of Public Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Rosa AlatiSchool of Public Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Curtin University · AUNorwegian Institute of Public Health · NOThe University of Queensland · AU

Funding

Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009
6 · The paper itself

Abstract

purposeIt is plausible that offspring born to mothers using tobacco during pregnancy may have increased risk of mood disorders (depression and bipolar disorders); however, mixed results have been reported. We conducted a systematic review and meta-analysis to investigate the magnitude and consistency of associations reported between prenatal tobacco use and mood disorders in offspring.

methodsWe systematically searched EMBASE, SCOPUS, PubMed and Psych-INFO for studies on mood disorders and prenatal tobacco use. Methodological quality of studies was assessed with the revised Newcastle-Ottawa Scale. We estimated pooled relative risk (RR) with inverse variance weighted random-effects meta-analysis. We performed leave-one-out analyses, and stratified analyses by a subgroup (depression and bipolar disorder). Potential publication bias was assessed by inspection of the funnel plot and Egger's test for regression asymmetry. This study protocol was prospectively registered in PROSPERO (CRD42017060037).

resultsEight cohort and two case-control studies were included in the final meta-analysis. We found an increased pooled relative risk of mood disorders in offspring exposed to maternal prenatal tobacco use RRs 1.43 (95% CI 1.27-1.60) compared to no prenatal tobacco use. Similarly, the pooled relative risks of bipolar and depressive disorders in offspring were 1.44, (95% CI 1.15-1.80) and 1.44, (95% CI 1.21-1.71), respectively. Moreover, the pooled estimated risk of mood disorders was not significantly attenuated in the studies that reported sibling comparison results [RR = 1.21 (95% CI 1.04-1.41)].

conclusionTaken together, there was strong evidence for a small (RR < 2) association between prenatal tobacco use and mood disorders in offspring.

Indexed as

Mood DisordersPrenatal Exposure Delayed EffectsTobacco UseCohort StudiesFemaleHumansMothersPregnancyRiskBipolar disorderDepressionMeta-analysisMood disordersOffspringPrenatalSystematic reviewTobacco

Identifiers

PMID32895729
OpenAlexW3084190512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.