ArticleNew microbes and new infections2020
Statins-based prophylactic mouthwash and nasal spray may protect against coronavirus disease 2019.
Article in New microbes and new infections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Review
- Advances in the Prophylaxis of Respiratory Infections by the Nasal and the Oromucosal Route: Relevance to the Fight with the SARS-CoV-2 Pandemic.Pharmaceutics · 2022Review
- Improved COVID-19 ICU admission and mortality outcomes following treatment with statins: a systematic review and meta-analysis.Archives of medical science : AMS · 2021Review
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The novel coronavirus 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented healthcare crisis. SARS-CoV-2 gets access into the human body mainly through the nose and the mouth and invades these mucosae in its destination to the pulmonary tissues. Thus, the oral and nasal mucosae serve as the main routes and reservoirs for aerosolized transmission of the viral particles to the external environment and hence infection transmission. Statins have been shown to have antimicrobial, antiviral, antifungal, anti-inflammatory, immunomodulatory, and antioxidant properties. Therefore, we hypothesize that using statins-based prophylactic mouthwashes will reduce COVID-19 transmission in dental settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.