ArticleNature metabolism2020
Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats.
Open access · greenAbstract read
In one paragraph
Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 63 citations in OpenAlex.
- Horizontal transfer of mitochondria in cancer: The physiology reborn in disease?Trends in cell biology · 2026Review
- Preliminary Comparative Analysis of Circulatory Glycosaminoglycan Concentrations and Disaccharide Profiles in Diabetic and Healthy Subjects.The Eurasian journal of medicine · 2026Article
- Beyond satiety: unraveling the complex roles of POMC neurons in behavior and metabolism.Reviews in endocrine & metabolic disorders · 2026Review
- Environmental Enrichment Preserves Retrosplenial Parvalbumin Density and Cognitive Function in Female 5xFAD Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Brain Nutrient Sensing: A Unifying Framework.Annual review of physiology · 2026Review
- THIK-1 channel mediates microglial glucose sensing and modulates AgRP neurons.bioRxiv : the preprint server for biology · 2026Article
- Central neural circuits and their associated mechanisms of inter-organ crosstalk.Frontiers in cell and developmental biology · 2026Review
- Sustained diabetes remission induced by FGF1 involves a shift in transcriptionally distinct AgRP neuron subpopulations.Molecular metabolism · 2026Article
- Characterization of Perineuronal Nets in the Paraventricular Nucleus of the Hypothalamus and their Alteration in Neurogenic Hypertension.Cellular and molecular neurobiology · 2025Article
- Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Characterization of Perineuronal Nets (PNNs) in the Paraventricular Nucleus of the Hypothalamus (PVN) and their alteration in neurogenic hypertension.Research square · 2025Article
- Glycosaminoglycan sugar side chains on perineuronal nets in the fastigial nucleus regulate motor skills.iScience · 2025Article
- Orchestrating the Matrix: The Role of Glial Cells and Systemic Signals in Perineuronal Net Dynamics.Neurochemical research · 2025Review
- A key role for parabrachial nucleus CGRP neurons in FGF1-Induced anorexia.Molecular metabolism · 2025Article
- Hypothalamic Gliosis Is Associated With Multiple Cardiovascular Disease Risk Factors in the Framingham Heart Study.Journal of the American Heart Association · 2025Article
- FGF-based drug discovery: advances and challenges.Nature reviews. Drug discovery · 2025Review
- Microglia mediate the early-life programming of adult glucose control.Cell reports · 2025Article
- Brain Defense of Glycemia in Health and Diabetes.Diabetes · 2024Review
- Research Progress of Fibroblasts in Human Diseases.Biomolecules · 2024Review
- Article
Corrections and comments
- Commented on by
Authors and funding
14 authors at 6 institutions in 2 countries.
Kimberly M AlongeUniversity of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2171-1640
Zaman MirzadehDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
Jarrad M ScarlettUniversity of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Aric F LogsdonDepartment of Geriatric Research Education and Clinical Center (GRECC), Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA, USA.
Jenny M BrownUniversity of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5072-4491
Elaine CabralesDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
Christina K ChanMatrix Biology Program, Benaroya Research Institute, Seattle, WA, USA.
Karl J KaiyalaDepartment of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, WA, USA.
Marie A BentsenUniversity of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2561-2308
William A BanksDepartment of Geriatric Research Education and Clinical Center (GRECC), Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA, USA.
Miklos GuttmanDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
Thomas N WightMatrix Biology Program, Benaroya Research Institute, Seattle, WA, USA.
Gregory J MortonUniversity of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8106-8386
Michael W SchwartzUniversity of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA. mschwart@uw.edu.ORCID http://orcid.org/0000-0003-1619-0331
University of Washington · USBarrow Neurological Institute · USMatrix Research (United States) · USUniversity of Puget Sound · USSeattle Children's Hospital · USUniversity of Copenhagen · DK
Funding
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4MPILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4MTransitioning Early Career Neurosurgeons to Scientific IndependenceK12NS080223 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ESKANDAR, EMAD N · 2012 to 2022
$9.2MNovel Brain Mechanisms Controlling Glucose HomeostasisR01DK083042 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2008 to 2025
$7.6MNeurobehavior, Neuropathology, and Risk Factors in Alzheimer's DiseaseT32AG052354 · NIA · UNIVERSITY OF WASHINGTON · PI Brian C. Kraemer, ELAINE R. PESKIND · 2016 to 2026
$6.7MNutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4MNeuroendocrine Control of Glucose MetabolismR01DK089056 · NIDDK · UNIVERSITY OF WASHINGTON · PI MORTON, GREGORY J · 2011 to 2024
$5.6MNovel Anti-Diabetic Actions of Hypothalamic FGF19-FGFR1 SignalingR01DK101997 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2014 to 2018
$1.9MHybrid structural mass spectrometry for rapid site-specific glycan structural elucidationR01GM127579 · NIGMS · UNIVERSITY OF WASHINGTON · PI GUTTMAN, MIKLOS · 2018 to 2021
$1.7MCentral and Peripheral Mechanisms of FGF1-Mediated Remission of Diabetic HyperglycemiaK08DK114474 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCARLETT, JARRAD M · 2017 to 2021
$813kThe role of tanycyte cilia in hypothalamic neurogenesis and glucose sensingF32DK108596 · NIDDK · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI MIRZADEH, ZAMAN · 2016 to 2017
$134kNovel role of hypothalamic perineuronal nets in the pathogenesis of type 2 diabetesF32DK122662 · NIDDK · UNIVERSITY OF WASHINGTON · PI ALONGE, KIMBERLY MICHELE · 2019 to 2019
$62kNHLBI NIH HHS T32 HL007028NIA NIH HHS T32 AG052354NIDDK NIH HHS F32 DK108596NIDDK NIH HHS F32 DK122662NIDDK NIH HHS K08 DK114474NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK083042NIDDK NIH HHS R01 DK089056NIDDK NIH HHS R01 DK101997NIGMS NIH HHS R01 GM127579NINDS NIH HHS K12 NS080223
Abstract
We recently showed that perineuronal nets (PNNs) enmesh glucoregulatory neurons in the arcuate nucleus (Arc) of the mediobasal hypothalamus (MBH)
Indexed as
Extracellular MatrixNeuronsAgedAnimalsBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2EatingFibroblast Growth Factor 1HumansHypothalamusInjections, IntraventricularMaleMiddle AgedBlood GlucoseFibroblast Growth Factor 1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.