ArticleNature metabolism2020
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes.
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Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56citing papers in PubMed
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Who cites it
56 citing papers in PubMed.
- Article
- Stem cell-based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection.Animal models and experimental medicine · 2026Review
- Microbiota-Targeted Chitooligosaccharides Intervention Restores Glucose Homeostasis After Islet Cell Transplantation in Rapamycin-Treated Mice.Food science & nutrition · 2026Article
- Spatially controlled Islet delivery into a bioengineered vascular Niche improves subcutaneous transplantation.Biomedical microdevices · 2026Article
- Article
- Vascularization of Human Pancreatic Islets With Adaptive Endothelial Cells for In Vitro Analysis and In Vivo Transplantation.Bio-protocol · 2025Article
- Anti-CD3 microporous annealed particle hydrogel protects stem cell derived beta cells from autoreactive T cells.bioRxiv : the preprint server for biology · 2025Article
- Nanotechnology-driven advancements in organ transplantation: Multifaceted strategies for organ preservation, ischemia reperfusion injury, immunomodulation and post-transplant monitoring.Materials today. Bio · 2025Review
- Hypoxia and Multilineage Communication in 3D Organoids for Human Disease Modeling.Biomimetics (Basel, Switzerland) · 2025Review
- Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy.American journal of physiology. Cell physiology · 2025Review
- Nanoparticle contrast-enhanced computed tomography and magnetic resonance imaging of vascularization of a subcutaneous niche for islet transplantation.Bioengineering & translational medicine · 2025Article
- The IsletTester Mouse: An Immunodeficient Model With Stable Hyperglycemia for the Study of Human Islets.Diabetes · 2025Article
- Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment.Science advances · 2025Article
- From Edmonton to Lantidra and beyond: immunoengineering islet transplantation to cure type 1 diabetes.Frontiers in transplantation · 2025Review
- Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead.Nature reviews. Endocrinology · 2025Review
- Establishment of subcutaneous transplantation platform for delivering induced pluripotent stem cell-derived insulin-producing cells.PloS one · 2025Article
- Biotechnology Revolution Shaping the Future of Diabetes Management.Biomolecules · 2024Review
- Diabetes current and future translatable therapies.Endocrine · 2024Review
- The role of fetal pancreatic islet cell transplantation in the treatment of type 2 diabetes mellitus.Journal of diabetes and metabolic disorders · 2024Article
- Inflammation-induced subcutaneous neovascularization for the long-term survival of encapsulated islets without immunosuppression.Nature biomedical engineering · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Ming Yu *Division of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Divyansh Agarwal *Division of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. divyansh.agarwal@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-0404-6877
Laxminarayana KorutlaDivision of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Catherine L MayInstitute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wei WangDivision of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Negin Noorchashm GriffithGriffith Center for Restorative Surgery, Red Bank, NJ, USA.
Bernhard J HeringSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-5962-7284
Klaus H KaestnerInstitute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Omaida C VelazquezDivision of Vascular Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
James F MarkmannDivision of Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2762-6535
Prashanth VallabhajosyulaDivision of Cardiothoracic Surgery, Yale University School of Medicine, New Haven, CT, USA.
Chengyang LiuDivision of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. chliu@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-9812-1676
Ali NajiDivision of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. Ali.Naji@uphs.upenn.edu.ORCID http://orcid.org/0000-0002-6926-3306
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MVIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3MPenn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8MB-Lymphocyte Immunotherapy in Islet TransplantationU01DK070430 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI NAJI, ALI · 2004 to 2011
$10.1MISOLATION/DISTRIBUTION OF HUMAN PANCREATIC ISLETSU42RR016600 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI NAJI, ALI · 2001 to 2008
$5.8MTargeting Blys/Baff in non-human primate islet transplantationU01AI102430 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI NAJI, ALI · 2012 to 2016
$4.0MNCATS NIH HHS UL1 TR001863NCRR NIH HHS U42 RR016600NIAID NIH HHS U01 AI102430NIDDK NIH HHS P30 DK019525NIDDK NIH HHS U01 DK070430NIDDK NIH HHS UC4 DK112217
Abstract
The intrahepatic milieu is inhospitable to intraportal islet allografts
Indexed as
AnimalsBlood GlucoseDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Glucose Transporter Type 2Graft SurvivalHeterograftsHumansIslets of Langerhans TransplantationMacaca fascicularisMiceMice, Inbred BALB CModels, AnimalSubcutaneous TissueSwineBlood GlucoseGlucose Transporter Type 2SLC2A2 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.