ArticleNature medicine2020
Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure.
Open access · greenAbstract readEvaluation Study
In one paragraph
Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
19.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 135 citations in OpenAlex.
- Updated Protocols for 3D and 2D Culture and Histological Analysis of Intestinal Organoids.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Biological Insights into Intestinal Adaptation from Preclinical Models of Short Bowel Syndrome.Cells · 2026Review
- Building and regenerating intestines by manipulating intestinal stem cells.Nature reviews. Gastroenterology & hepatology · 2026Review
- Autogenic-regenerated intestinal transplantation improves outcomes in short bowel syndrome.JCI insight · 2026Article
- Generation of biologically responsive colon-like intestinal tissue patches from human induced pluripotent stem cells using a rapid co-differentiation platform.Stem cell research & therapy · 2026Article
- Peptide-based Wnt signal activation enables scalable production of clinical-grade patient-derived intestinal organoids for regenerative cell therapy.Stem cell research & therapy · 2026Article
- The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ.Immunological reviews · 2026Review
- Organoid Technology as a Promising Frontier in Organ Transplantation and Regenerative Medicine.International journal of stem cells · 2026Review
- Stem Cell Therapy for Inflammatory Diseases: Progress, Challenges, and Future Directions.MedComm · 2026Review
- Human gastric multi-regional assembloids for functional parietal maturation and patient-specific modelling of antral foveolar hyperplasia.Nature biomedical engineering · 2026Article
- Transcriptomic profiling reveals substrate- and shear stress-dependent maturation of human small intestinal epithelial cells.Frontiers in pharmacology · 2026Article
- The functional role of the extracellular matrix in inflammatory bowel disease associated gut fibrosis.Matrix biology : journal of the International Society for Matrix Biology · 2025Review
- Establishment of an Organoid Culture Model Derived from Small Intestinal Epithelium of C57BL/6 Mice and Its Benefits over Tissues.Journal of cancer prevention · 2025Article
- Article
- Towards high-accuracy bacterial taxonomy identification using phenotypic single-cell Raman spectroscopy data.ISME communications · 2025Article
- Controlled aggregative assembly to form self-organizing macroscopic human intestine from induced pluripotent stem cells.Cell reports methods · 2024Article
- Establishment of a 3D organoid culture model for the investigation of adult slow-cycling putative intestinal stem cells.Histochemistry and cell biology · 2024Article
- An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis.Nature biomedical engineering · 2024Article
- Bioengineering of Intestinal Grafts.Gastroenterology clinics of North America · 2024Review
- Tissue engineering and regenerative medicine approaches in colorectal surgery.Annals of coloproctology · 2024Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 3 institutions in 2 countries.
Laween MeranStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-1802-1905
Isobel MassieStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.
Sara CampinotiStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.
Anne E WestonStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.
Riana GaifulinaDepartment of Cell and Developmental Biology, University College London, London, UK.
Lucinda TullieStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.
Peter FaullStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-8491-8086
Michael OrfordStem Cell and Regenerative Medicine Section, DBC, Great Ormond Street Institute of Child Health, University College London, London, UK.
Anna KucharskaStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.
Anna BauliesStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.
Laura NovellasdemuntStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.
Nikolaos AngelisStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.
Elizabeth HirstStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.
Julia KönigStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.
Alfonso Maria TedeschiStem Cell and Regenerative Medicine Section, DBC, Great Ormond Street Institute of Child Health, University College London, London, UK.
Alessandro Filippo PellegataStem Cell and Regenerative Medicine Section, DBC, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-5618-4641
Susanna EliStem Cell and Regenerative Medicine Section, DBC, Great Ormond Street Institute of Child Health, University College London, London, UK.
Ambrosius P SnijdersStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-5416-8592
Lucy CollinsonStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-0260-613X
Nikhil ThaparStem Cell and Regenerative Medicine Section, DBC, Great Ormond Street Institute of Child Health, University College London, London, UK.
Geraint M H ThomasDepartment of Cell and Developmental Biology, University College London, London, UK.ORCID http://orcid.org/0000-0003-4035-7832
Simon EatonStem Cell and Regenerative Medicine Section, DBC, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0003-0892-9204
Paola BonfantiStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK.
Paolo De CoppiStem Cell and Regenerative Medicine Section, DBC, Great Ormond Street Institute of Child Health, University College London, London, UK. p.decoppi@ucl.ac.uk.ORCID http://orcid.org/0000-0002-1659-0207
Vivian S W LiStem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK. vivian.li@crick.ac.uk.ORCID http://orcid.org/0000-0003-2041-0085
The Francis Crick Institute · GBGreat Ormond Street Hospital · GBUniversity College London · GB
Funding
Cancer Research UK FC001105Department of HealthMedical Research Council FC001105Medical Research Council MC_PC_14118Medical Research Council MR/N028414/1Wellcome Trust FC001105
Abstract
Intestinal failure, following extensive anatomical or functional loss of small intestine, has debilitating long-term consequences for children
Indexed as
AnimalsCell DifferentiationCell ProliferationCells, CulturedChildEnterocytesExtracellular MatrixFemaleHEK293 CellsHumansHuman Umbilical Vein Endothelial CellsIntestinal DiseasesIntestinal MucosaJejunumMiceMice, Inbred NOD
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.