ArticleNature neuroscience2020
Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Reductionism in Engram Neuroscience.The European journal of neuroscience · 2026Review
- Persistence of vestibular function in the absence of glutamatergic transmission from hair cells.Scientific reports · 2026Article
- Coordination of spike timing among the neurons of the cerebellum.Research square · 2026Article
- Regular afferent activity and structural homogeneity gate ephaptic synchronization in the dorsal column.Frontiers in human neuroscience · 2026Article
- Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons.bioRxiv : the preprint server for biology · 2025Article
- Coordination of spike timing among the neurons of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Reproducible Human Neural Circuits Printed with Single-Cell Precision Reveal the Functional Roles of Ephaptic Coupling.ACS nano · 2025Article
- Processing reliant on granule cells is essential for motor learning but dispensable for social preference and numerous other cerebellar-dependent behaviors.Nature communications · 2025Article
- Climbing fibers selectively recruit disinhibitory interneurons to enhance dendritic calcium signaling in cerebellar Purkinje cells.bioRxiv : the preprint server for biology · 2025Article
- Article
- An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The cerebellum engages multiple pre-motor pathways through a divergent-convergent architecture to shape whisker dynamics.Frontiers in neural circuits · 2025Article
- Characterization of direct Purkinje cell outputs to the brainstem.bioRxiv : the preprint server for biology · 2024Article
- TAG-SPARK: Empowering High-Speed Volumetric Imaging With Deep Learning and Spatial Redundancy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Review
- Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: a computational modeling study.Journal of neurophysiology · 2024Article
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.eLife · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Climbing fibers from the inferior olive make strong excitatory synapses onto cerebellar Purkinje cell (PC) dendrites and trigger distinctive responses known as complex spikes. We found that, in awake mice, a complex spike in one PC suppressed conventional simple spikes in neighboring PCs for several milliseconds. This involved a new ephaptic coupling, in which an excitatory synapse generated large negative extracellular signals that nonsynaptically inhibited neighboring PCs. The distance dependence of complex spike-simple spike ephaptic signaling, combined with the known CF divergence, allowed a single inferior olive neuron to influence the output of the cerebellum by synchronously suppressing the firing of potentially over 100 PCs. Optogenetic studies in vivo and dynamic clamp studies in slice indicated that such brief PC suppression, as a result of either ephaptic signaling or other mechanisms, could effectively promote firing in neurons in the deep cerebellar nuclei with remarkable speed and precision.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.