ArticleNature immunology2020
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression.
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In one paragraph
Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
132 citing papers in PubMed, 1 synthesis or guideline pooled it, 191 citations in OpenAlex.
- Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2023Pooled it
- Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Mouse Models of Atherosclerosis: What They Teach Us, What They Miss, and When to Use Them.Bioengineering (Basel, Switzerland) · 2026Review
- Screening for candidate genes and cell populations associated with atherosclerotic calcification using single-cell RNA sequencing.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Single-cell transcriptomics uncovers endothelial progenitor-like remodelling driving human coronary atherosclerosis progression.Nature cell biology · 2026Article
- Single-cell spatial transcriptomics reveals clonal smooth muscle cell heterogeneity and programs associated with atherosclerotic plaque calcification.Clinical and experimental medicine · 2026Article
- Fitness Training for γδ T cells in mouse and human atherosclerosis takes place in plaques and artery tertiary lymphoid organs.Genome medicine · 2026Article
- Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation.Nature communications · 2026Article
- Environmental modulators of vascular physiology and inflammation.Experimental physiology · 2026Review
- A Road Map to Understanding Cardiovascular Disease in Diabetes: From the AHA Strategically Focused Research Network in Cardiometabolic Health and Type 2 Diabetes.Circulation research · 2026Review
- Review
- A guide to cell-type-specific Cre mouse models in atherosclerosis: from background strains to future directions.Frontiers in cardiovascular medicine · 2026Review
- Hypoxia-inducible factors link inflammation and lipid metabolism in atherosclerotic macrophages.Frontiers in cardiovascular medicine · 2026Review
- T cells in cardiovascular disease: solved and unsolved mysteries.Science China. Life sciences · 2026Review
- The role of macrophages in aortic physiology and pathophysiology.Frontiers in immunology · 2026Review
- LIPA, a risk locus for coronary artery disease: decoding the variant-to-function relationship.European heart journal · 2025Article
- Interleukin-38 Ameliorates Atherosclerosis by Inhibiting Macrophage M1-like Polarization and Apoptosis.Biomolecules · 2025Article
- Foam cells: tracing the diverse cellular origins and their linked signaling pathways.Journal of translational medicine · 2025Review
- Macrophage Phospholipase D3 promotes atherosclerosis via exacerbating foam cell formation and inducing inflammatory responses.International journal of cardiology. Heart & vasculature · 2025Article
- CRISPR-MI and scRNA-Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 7 institutions in 5 countries.
Jesse W WilliamsDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA. jww@umn.edu.ORCID http://orcid.org/0000-0003-3815-0891
Konstantin ZaitsevComputer Technologies Department, ITMO University, Saint Petersburg, Russia.
Ki-Wook KimDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Stoyan IvanovDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Brian T SaundersDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Patricia R SchrankDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Kyeongdae KimDepartment of Life Science, College of Natural Sciences, Research Institute of Natural Sciences, Hanyang University, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-7545-6366
Andrew ElvingtonDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Seung Hyeon KimDepartment of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA.
Christopher G TuckerCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Mary WohltmannDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Brian T FifeCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-9826-5637
Slava EpelmanDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0003-3400-4475
Maxim N ArtyomovDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-1133-4212
Kory J LavineDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Bernd H ZinselmeyerDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Jae-Hoon ChoiDepartment of Life Science, College of Natural Sciences, Research Institute of Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Gwendalyn J RandolphDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0001-9045-1195
Washington University in St. Louis · USIllinois College · USUniversity of Minnesota Medical Center · USHanyang University · KRInserm · FRITMO University · RUUniversity of Toronto · CA
Funding
Type I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HOGQUIST, KRISTIN A. · 1993 to 2023
$31.1MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1MDIABETES &RELATED METABOLIC DISEASEST32DK007120 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Maria Sara Remedi · 1986 to 2026
$15.7MIMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7MDIFFERENTIATION AND FUNCTION OF MONOCYTES AND MACROPHAGESR37AI049653 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2016 to 2025
$4.3MINTEGRATING CELL & LIPOPROTEIN TRAFFICKING WITH VASCULAR BIOLOGY IN HUMAN IBDDP1DK109668 · NIDDK · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2015 to 2019
$3.8MMACROPHAGE HETEROGENEITY IN HEART FAILURE PROGRESSION AND CARDIAC RECOVERYR01HL138466 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2017 to 2021
$1.9MMACROPHAGE ONTOGENY SHIFTS IN ISCHEMIC HEART DISEASER01HL139714 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2018 to 2021
$1.5MATHEROSCLEROTIC LESION INITIATION BY RESIDENT AORTIC MACROPHAGE PROLIFERATIONR00HL138163 · NHLBI · UNIVERSITY OF MINNESOTA · PI WILLIAMS, JESSE WARREN · 2019 to 2021
$747kEMBRYONIC-DERIVED MACROPHAGES IN CORONARY DEVELOPMENT AND ADULT CORONARY GROWTHK08HL123519 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2014 to 2018
$715kATHEROSCLEROTIC LESION INITIATION BY RESIDENT AORTIC MACROPHAGE PROLIFERATION AND LIPID UPTAKEK99HL138163 · NHLBI · WASHINGTON UNIVERSITY · PI WILLIAMS, JESSE WARREN · 2018 to 2018
$125kAmerican Heart Association-American Stroke Association 17POST33410473NHLBI NIH HHS K08 HL123519NHLBI NIH HHS K99 HL138163NHLBI NIH HHS R00 HL138163NHLBI NIH HHS R01 HL138466NHLBI NIH HHS R01 HL139714NIAID NIH HHS P01 AI035296NIAID NIH HHS R37 AI049653NIAID NIH HHS T32 AI007313NIDDK NIH HHS DP1 DK109668NIDDK NIH HHS P30 DK020579NIDDK NIH HHS T32 DK007120
Abstract
Early atherosclerosis depends upon responses by immune cells resident in the intimal aortic wall. Specifically, the healthy intima is thought to be populated by vascular dendritic cells (DCs) that, during hypercholesterolemia, initiate atherosclerosis by being the first to accumulate cholesterol. Whether these cells remain key players in later stages of disease is unknown. Using murine lineage-tracing models and gene expression profiling, we reveal that myeloid cells present in the intima of the aortic arch are not DCs but instead specialized aortic intima resident macrophages (Mac
Indexed as
AnimalsAortaCell DifferentiationCell LineageCell MovementCell ProliferationCells, CulturedCholesterolDisease ProgressionHumansMacrophage Colony-Stimulating FactorMacrophagesMiceMice, Inbred C57BLMice, TransgenicMonocytesCholesterolCSF1 protein, mouseMacrophage Colony-Stimulating Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.