Evidence map›Paper›PMID 32895515›Full record

ArticleNature biomedical engineering2020

Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery.

Mengdi Han, Lin Chen, Kedar Aras, Cunman Liang, Xuexian Chen, Hangbo Zhao, Kan Li, Ndeye Rokhaya Faye, Bohan Sun, Jae-Hwan Kim and 14 more

Abstract read
In one paragraph

Article in Nature biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed.

  1. Soft robotic devices for cardiovascular medicine.Nature reviews. Cardiology · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Tissue-bioelectronics interfaces.Chemical Society reviews · 2026
    Review
  10. Article
  11. Smart Catheters for Diagnosis, Monitoring, and Therapy.Advanced healthcare materials · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Mengdi Han *Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-7552-7398
Lin Chen *Departments of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA.
Kedar Aras *Department of Biomedical Engineering, The George Washington University, Washington, DC, USA.ORCID http://orcid.org/0000-0002-9898-1462
Cunman LiangKey Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, School of Mechanical Engineering, Tianjin University, Tianjin, China.
Xuexian ChenAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Hangbo ZhaoQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Kan LiDepartments of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA.
Ndeye Rokhaya FayeDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA.
Bohan SunQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Jae-Hwan KimFrederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign Urbana, Champaign, IL, USA.
Wubin BaiQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Quansan YangDepartment of Mechanical Engineering, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0001-8029-1327
Yuhang MaQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Wei LuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Enming SongQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-2658-904X
Janice Mihyun BaekDepartment of Chemistry, University of Illinois at Urbana-Champaign Urbana, Champaign, IL, USA.
Yujin LeeDepartment of Chemistry, University of Illinois at Urbana-Champaign Urbana, Champaign, IL, USA.
Clifford LiuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Jeffrey B ModelQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Guanjun YangState Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, China.
Roozbeh GhaffariQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0001-5380-2363
Yonggang HuangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA. y-huang@northwestern.edu.ORCID http://orcid.org/0000-0002-0483-8359
Igor R EfimovDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA. efimov@gwu.edu.ORCID http://orcid.org/0000-0002-1483-5039
John A RogersQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.ORCID http://orcid.org/0000-0002-2980-3961

Funding

TRD - VisualizationP41GM103545 · NIGMS · UNIVERSITY OF UTAH · PI JOHNSON, CHRISTOPHER R. · 2012 to 2019
$9.7M
High-Definition Conformal Electronics for VT/VFR01HL141470 · NHLBI · NORTHWESTERN UNIVERSITY · PI EFIMOV, IGOR R · 2019 to 2022
$2.5M
Center for Integrative Biomedical Computing Legacy TransitionR24GM136986 · NIGMS · UNIVERSITY OF UTAH · PI JOHNSON, CHRISTOPHER R., MACLEOD, ROB S. · 2020 to 2022
$1.6M
Role of epicardial adiposity as a local mediator of VT/VF dynamics in donor human heartsK99HL148523 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI ARAS, KEDAR KIRTIKUMAR · 2020 to 2021
$198k
NHLBI NIH HHS K99 HL148523NHLBI NIH HHS R01 HL141470NIGMS NIH HHS P41 GM103545NIGMS NIH HHS R24 GM136986
6 · The paper itself

Abstract

The rigidity and relatively primitive modes of operation of catheters equipped with sensing or actuation elements impede their conformal contact with soft-tissue surfaces, limit the scope of their uses, lengthen surgical times and increase the need for advanced surgical skills. Here, we report materials, device designs and fabrication approaches for integrating advanced electronic functionality with catheters for minimally invasive forms of cardiac surgery. By using multiphysics modelling, plastic heart models and Langendorff animal and human hearts, we show that soft electronic arrays in multilayer configurations on endocardial balloon catheters can establish conformal contact with curved tissue surfaces, support high-density spatiotemporal mapping of temperature, pressure and electrophysiological parameters and allow for programmable electrical stimulation, radiofrequency ablation and irreversible electroporation. Integrating multimodal and multiplexing capabilities into minimally invasive surgical instruments may improve surgical performance and patient outcomes.

Indexed as

Cardiac CathetersAnimalsCatheter AblationElectronicsElectroporationEquipment DesignFemaleFinite Element AnalysisHeart VentriclesHumansMonitoring, IntraoperativePressureRabbitsTemperature

Identifiers

PMID32895515
PMCPMC8021456

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.