Evidence map›Paper›PMID 32895507›Full record

ArticleNature materials2021

ILC1 drive intestinal epithelial and matrix remodelling.

Geraldine M Jowett, Michael D A Norman, Tracy T L Yu, Patricia Rosell Arévalo, Dominique Hoogland, Suzette T Lust, Emily Read, Eva Hamrud, Nick J Walters, Umar Niazi and 15 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 112 citations in OpenAlex.

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  11. The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  12. Innate Lymphoid Cells Are the Rheostat of Immune Response in the Kidney.Journal of cellular and molecular medicine · 2025
    Review
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 8 institutions in 5 countries.

Geraldine M JowettCentre for Craniofacial and Regenerative Biology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-8436-6637
Michael D A Norman *Centre for Craniofacial and Regenerative Biology, King's College London, London, UK.
Tracy T L Yu *Centre for Craniofacial and Regenerative Biology, King's College London, London, UK.
Patricia Rosell ArévaloCentre for Host Microbiome Interactions, King's College London, London, UK.
Dominique HooglandDepartment of Chemistry, King's College London, London, UK.ORCID http://orcid.org/0000-0002-1655-2833
Suzette T LustCentre for Craniofacial and Regenerative Biology, King's College London, London, UK.
Emily ReadCentre for Host Microbiome Interactions, King's College London, London, UK.ORCID http://orcid.org/0000-0002-0376-2989
Eva HamrudCentre for Craniofacial and Regenerative Biology, King's College London, London, UK.
Nick J WaltersBioMediTech, Tampere University Tampere Finland, Helsinki, Finland.
Umar NiaziGuy's and St Thomas' National Health Service Foundation Trust and King's College London National Institute for Health Research Biomedical Research Centre Translational Bioinformatics Platform, Guy's Hospital, London, UK.ORCID http://orcid.org/0000-0001-7176-8883
Matthew Wai Heng ChungCentre for Host Microbiome Interactions, King's College London, London, UK.ORCID http://orcid.org/0000-0002-3627-5669
Daniele MarcianoCentre for Craniofacial and Regenerative Biology, King's College London, London, UK.
Omer S OmerSchool of Immunology and Microbial Sciences, King's College London, London, UK.
Tomasz ZabinskiCentre for Host Microbiome Interactions, King's College London, London, UK.
Davide DanoviCentre for Stem Cells & Regenerative Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0003-4119-5337
Graham M LordFaculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Jöns HilbornDepartment of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.
Nicholas D EvansBone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences, University of Southampton, Southampton, UK.
Cécile A DreissInstitute of Pharmaceutical Science, King's College London, London, UK.
Laurent BozecFaculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-6322-7817
Oommen P OommenBioengineering and Nanomedicine Lab, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0003-2768-0133
Christian D LorenzDepartment of Physics, King's College London, London, UK.
Ricardo M P da SilvaCentre for Craniofacial and Regenerative Biology, King's College London, London, UK.ORCID http://orcid.org/0000-0003-1456-8724
Joana F Neves *Centre for Host Microbiome Interactions, King's College London, London, UK. joana.pereira_das_neves@kcl.ac.uk.ORCID http://orcid.org/0000-0001-5842-4162
Eileen Gentleman *Centre for Craniofacial and Regenerative Biology, King's College London, London, UK. eileen.gentleman@kcl.ac.uk.ORCID http://orcid.org/0000-0003-0447-5137
King's College London · GBTampere University · FINational Health Service · GBSt Thomas' Hospital · GBUniversity of Manchester · GBUniversity of Southampton · GBUniversity of Toronto · CAUppsala University · SE

Funding

Department of HealthMedical Research Council G0802068Medical Research Council MR/K002996/1Medical Research Council MR/M003493/1Medical Research Council MR/N006445/1Medical Research Council MR/N013700/1Medical Research Council MR/R024812/1Medical Research Council MR/S00033X/1Wellcome Trust 091009Wellcome Trust 203757Wellcome Trust 203757/Z/16/AWellcome Trust 204394Wellcome Trust 204394/Z/16/ZWellcome Trust 215027Wellcome Trust 215027/Z/18/Z
6 · The paper itself

Abstract

Organoids can shed light on the dynamic interplay between complex tissues and rare cell types within a controlled microenvironment. Here, we develop gut organoid cocultures with type-1 innate lymphoid cells (ILC1) to dissect the impact of their accumulation in inflamed intestines. We demonstrate that murine and human ILC1 secrete transforming growth factor β1, driving expansion of CD44v6

Indexed as

AnimalsExtracellular MatrixFemaleHumansIntestinal MucosaLymphocytesMatrix Metalloproteinase 9MiceOrganoidsTransforming Growth Factor beta1Matrix Metalloproteinase 9MMP9 protein, humanMmp9 protein, mouseTGFB1 protein, humanTgfb1 protein, mouseTransforming Growth Factor beta1

Identifiers

PMID32895507
PMCPMC7611574
OpenAlexW3048560726

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.