ArticleThe ISME journal2021
Microbial interactions in the mosquito gut determine Serratia colonization and blood-feeding propensity.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Interactions Between Inbreeding, Fitness and the Bacterial Microbiome inEvolutionary applications · 2026Article
- Serratia marcescens and Enterobacter cloacae exhibit differential population dynamics in Anopheles gambiae s.l after sugar and blood feeding.Malaria journal · 2026Article
- Crop: The Black Box of Mosquito Vector Fitness.Insects · 2026Review
- Addition of a single bacterial isolate to conventional larval rearing water can impact wing size and longevity in adult malebioRxiv : the preprint server for biology · 2026Article
- Article
- Transplant of cryopreserved mosquito gut microbiota reveals strain-specific patterns of microbial acquisition and assembly.ISME host microbe · 2026Article
- Article
- Passive environmental and group-level processes drive gut microbiome composition in a wild corvid.Animal microbiome · 2025Article
- Mosquito host background impacts microbiome-Zika virus interactions in field- and laboratory-reared Aedes aegypti.Animal microbiome · 2025Article
- Bacterial infection elicits theOpen biology · 2025Article
- Leveraging microbial ecology for mosquito-borne disease control.Trends in parasitology · 2025Review
- Do the microbiota of larval breeding site and the blood meal influence the composition and diversity of bacterial communities in the midgut of Mansonia humeralis (Diptera: Culicidae) from the western Amazon?Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Reduced microbe abundance in an urban larval development container increases Aedes aegypti susceptibility to Zika virus.PLoS pathogens · 2025Article
- Harnessing engineered symbionts to combat concurrent malaria and arboviruses transmission.Nature communications · 2025Article
- Metabarcoding for the Monitoring of the Microbiome and Parasitome of Medically Important Mosquito Species in Two Urban and Semi-urban Areas of South Korea.Current microbiology · 2025Article
- Mosquitoes Reared in Nearby Insectaries at the Same Institution Have Significantly Divergent Microbiomes.Environmental microbiology · 2025Article
- Multi-omics profiling reveals associations between gut microbiota and olfactory gene expression in mosquitoes.Frontiers in cellular and infection microbiology · 2025Article
- MosAIC: An annotated collection of mosquito-associated bacteria with high-quality genome assemblies.PLoS biology · 2024Article
- Mosquitoes reared in distinct insectaries within an institution in close spatial proximity possess significantly divergent microbiomes.bioRxiv : the preprint server for biology · 2024Article
- Mosquito Gut Microbiota: A Review.Pathogens (Basel, Switzerland) · 2024Review
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Authors and funding
17 authors.
Funding
Abstract
How microbe-microbe interactions dictate microbial complexity in the mosquito gut is unclear. Previously we found that, Serratia, a gut symbiont that alters vector competence and is being considered for vector control, poorly colonized Aedes aegypti yet was abundant in Culex quinquefasciatus reared under identical conditions. To investigate the incompatibility between Serratia and Ae. aegypti, we characterized two distinct strains of Serratia marcescens from Cx. quinquefasciatus and examined their ability to infect Ae. aegypti. Both Serratia strains poorly infected Ae. aegypti, but when microbiome homeostasis was disrupted, the prevalence and titers of Serratia were similar to the infection in its native host. Examination of multiple genetically diverse Ae. aegypti lines found microbial interference to S. marcescens was commonplace, however, one line of Ae. aegypti was susceptible to infection. Microbiome analysis of resistant and susceptible lines indicated an inverse correlation between Enterobacteriaceae bacteria and Serratia, and experimental co-infections in a gnotobiotic system recapitulated the interference phenotype. Furthermore, we observed an effect on host behavior; Serratia exposure to Ae. aegypti disrupted their feeding behavior, and this phenotype was also reliant on interactions with their native microbiota. Our work highlights the complexity of host-microbe interactions and provides evidence that microbial interactions influence mosquito behavior.
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