Evidence map›Paper›PMID 32895467›Full record

ArticleScientific reports2020

TRPV6 calcium channel directs homeostasis of the mammary epithelial sheets and controls epithelial mesenchymal transition.

Tytti Kärki, Eeva Kaisa Rajakylä, Anna Acheva, Sari Tojkander

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Calcium channels as pharmacological targets for cancer therapy.Clinical and experimental medicine · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. CaInternational journal of molecular sciences · 2022
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Syndecan-1 (CD138), Carcinomas and EMT.International journal of molecular sciences · 2021
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tytti KärkiSection of Pathology, Department of Veterinary Biosciences, University of Helsinki, Agnes Sjöberginkatu 2, 00014, Helsinki, Finland.
Eeva Kaisa RajakyläSection of Pathology, Department of Veterinary Biosciences, University of Helsinki, Agnes Sjöberginkatu 2, 00014, Helsinki, Finland.
Anna AchevaSection of Pathology, Department of Veterinary Biosciences, University of Helsinki, Agnes Sjöberginkatu 2, 00014, Helsinki, Finland.
Sari TojkanderSection of Pathology, Department of Veterinary Biosciences, University of Helsinki, Agnes Sjöberginkatu 2, 00014, Helsinki, Finland. sari.tojkander@helsinki.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial integrity is lost upon cancer progression as cancer cells detach from the primary tumor site and start to invade to the surrounding tissues. Invasive cancers of epithelial origin often express altered levels of TRP-family cation channels. Upregulation of TRPV6 Ca

Indexed as

Epithelial-Mesenchymal TransitionActomyosinAdherens JunctionsBreast NeoplasmsCadherinsCalcium ChannelsCell LineCell Line, TumorEpithelial CellsFemaleHumansTRPV Cation ChannelsActomyosinCadherinsCalcium ChannelsTRPV6 protein, humanTRPV Cation Channels

Identifiers

PMID32895467
PMCPMC7477193

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.