ArticleScientific reports2020
Mechanism underlying hippocampal long-term potentiation and depression based on competition between endocytosis and exocytosis of AMPA receptors.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- A Systematic Review of the Effects of N-Methyl-D-Aspartate Receptor Antagonists on Pancreatic Islets.Neuroendocrinology · 2026Pooled it
- Pooled it
- Frequency-Dependent Whole-Brain Reconfiguration Following Left DLPFC rTMS in Older Adults: A 106-Channel fNIRS Study.Sensors (Basel, Switzerland) · 2026Trial
- Validity Assessment of a Three-Dimensional Printed Arthroscopic Shoulder Simulator: An Experimental Evaluation of Construct Validity and Educational Value.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Trial
- Sustained AMPAR expression in CA3 neurons may mediate neuroprotection following FLASH-RT.Cell reports · 2026Article
- Neuroprotection following FLASH-RT may be mediated by sustained glutamate receptor AMPAR activation in CA3 neurons.bioRxiv : the preprint server for biology · 2026Article
- The influence of neuro-tumor interactions on tumorigenesis and therapeutic response.Experimental hematology & oncology · 2026Review
- PKMζ is necessary for long-term depression and long-term potentiation in the medial prefrontal cortex.The Journal of physiology · 2026Article
- Common themes in evoked ion channel translocation in neuroplastic and homeostatic plasticity.Frontiers in pharmacology · 2026Review
- BDNF Signaling in Glutamatergic Neurons During Long-Term Potentiation (LTP): A Spatio-Temporal Exploration of Events.Molecular neurobiology · 2025Review
- Can Theta Burst Electromagnetic Fields Disrupt Learning in Planaria? Evidence of Impaired Fear-Conditioned Responses.Bioelectromagnetics · 2025Article
- A comprehensive review on adaptive plasticity and recovery mechanisms post-acquired brain injury.Neuroprotection (Chichester, England) · 2025Review
- Astrocytes of the hippocampus and responses to periprandial neuroendocrine hormones.Physiology & behavior · 2025Review
- The Oxytocin Neurons in the Paraventricular Nucleus Are Essential for Chronic Sleep Deprivation-Mediated Anxiety-Related Behaviors.CNS neuroscience & therapeutics · 2025Article
- Hippocampal-Specific Insulin Resistance Elicits Synaptic Effects on Glutamate Neurotransmission.Journal of neurochemistry · 2025Article
- Review
- Ligature-induced periodontitis in a transgenic mouse model of Alzheimer's disease dysregulates neuroinflammation, exacerbates cognitive impairment, and accelerates amyloid pathology.Brain, behavior, & immunity - health · 2025Article
- Future Perspectives of NMDAR in CNS Disorders.Molecules (Basel, Switzerland) · 2025Review
- Volume electron microscopy reveals unique laminar synaptic characteristics in the human entorhinal cortex.eLife · 2025Article
- AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases.Cellular and molecular neurobiology · 2025Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) and long-term depression (LTD) of signal transmission form neural circuits and thus are thought to underlie learning and memory. These mechanisms are mediated by AMPA receptor (AMPAR) trafficking in postsynaptic neurons. However, the regulatory mechanism of bidirectional plasticity at excitatory synapses remains unclear. We present a network model of AMPAR trafficking for adult hippocampal pyramidal neurons, which reproduces both LTP and LTD. We show that the induction of both LTP and LTD is regulated by the competition between exocytosis and endocytosis of AMPARs, which are mediated by the calcium-sensors synaptotagmin 1/7 (Syt1/7) and protein interacting with C-kinase 1 (PICK1), respectively. Our result indicates that recycling endosomes containing AMPAR are always ready for Syt1/7-dependent exocytosis of AMPAR at peri-synaptic/synaptic membranes. This is because molecular motor myosin V
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.