ArticleNature communications2020
Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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Who cites it
56 citing papers in PubMed.
- Arterial stiffness moderates the link between NfL and cognition: The IGNITE study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- From Fitness to Cognition: Machine-Learning Prediction of Cognitive Performance Using Physiological Parameters in Healthy Adults.Medicine and science in sports and exercise · 2026Article
- [Optimized decomposition of dynamic electroencephalography-functional near infrared spectroscopy brain functional networks for the analysis of repetitive transcranial magnetic stimulation combined with motor training].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- The active ingredients: physical activity features linked to healthy brain aging.Alzheimer's research & therapy · 2026Article
- Classifying cognitive status with TabCAT Match and UDS executive function tests.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Modelling cognitive outcomes in the UK Biobank: Education, noradrenaline and frontoparietal networks.PloS one · 2026Article
- Specific genetic and biological patterns underlying cortical morphological alterations in vascular cognitive impairment.Alzheimer's research & therapy · 2025Article
- The relationship between neuropsychiatric dimensions and markers of Parkinson's disease risk in the UK Biobank.NPJ Parkinson's disease · 2025Article
- Cardiorespiratory fitness and cardiometabolic health are associated with distinct cognitive domains in cognitively healthy older adults.Scientific reports · 2025Article
- Hospital-treated infectious diseases and the risk of epilepsy in older age.Nature aging · 2025Article
- Polygenic risk for Alzheimer's disease in healthy aging: age-related and APOE-driven effects on brain structures and cognition.Genome medicine · 2025Article
- Body mass index-specific metabolic profiles in schizophrenia: implications for cognitive dysfunction and psychopathology.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Association of multimorbidity and disease clusters with neuroimaging and cognitive outcomes in UK Biobank.The journal of prevention of Alzheimer's disease · 2025Article
- Age and gender-related patterns of arterial transit time and cerebral blood flow in healthy adults.NeuroImage · 2025Article
- Cerebrovascular health impacts processing speed through anterior white matter alterations: a UK biobank study.Scientific reports · 2025Article
- Detection of cognitive deficits years prior to clinical diagnosis across neurological conditions.Brain communications · 2025Article
- Decoding the best automated segmentation tools for vascular white matter hyperintensities in the aging brain: a clinician's guide to precision and purpose.GeroScience · 2024Article
- Modifiable dementia risk factors associated with objective and subjective cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Association between household size and risk of incident dementia in the UK Biobank study.Scientific reports · 2024Article
- The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease.Nature communications · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Healthy cognitive ageing is a societal and public health priority. Cerebrovascular risk factors increase the likelihood of dementia in older people but their impact on cognitive ageing in younger, healthy brains is less clear. The UK Biobank provides cognition and brain imaging measures in the largest population cohort studied to date. Here we show that cognitive abilities of healthy individuals (N = 22,059) in this sample are detrimentally affected by cerebrovascular risk factors. Structural equation modelling revealed that cerebrovascular risk is associated with reduced cerebral grey matter and white matter integrity within a fronto-parietal brain network underlying executive function. Notably, higher systolic blood pressure was associated with worse executive cognitive function in mid-life (44-69 years), but not in late-life (>70 years). During mid-life this association did not occur in the systolic range of 110-140 mmHg. These findings suggest cerebrovascular risk factors impact on brain structure and cognitive function in healthy people.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.