Evidence map›Paper›PMID 32895178›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2020

[Inhibitory effect of ketogenic diet on neuroblastoma in BALB/c-nu mouse models].

Jiaojiao He, Linya Lü, Junwei Peng, Changchun Li, Xiangru Kong, Jun Zhang, Liang Peng

Open access · greenAbstract read
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiaojiao HeDepartment of Oncology Surgery, Chongqing 400014, China.
Linya LüDepartment of Oncology Surgery, Chongqing 400014, China.
Junwei PengDepartment of Oncology Surgery, Chongqing 400014, China.
Changchun LiDepartment of Oncology Surgery, Chongqing 400014, China.
Xiangru KongDepartment of Oncology Surgery, Chongqing 400014, China.
Jun ZhangDepartment of Oncology Surgery, Chongqing 400014, China.
Liang PengDepartment of Oncology Surgery, Chongqing 400014, China.
Chongqing Cancer Hospital · CNChina International Science and Technology Cooperation · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the inhibitory effect of ketogenic diet (KD) on growth of neuroblastoma in mice.

methodsBALB/c-nu mouse models bearing neuroblastoma xenografts were established by subcutaneous injection of human neuroblastoma cell line (SH-SY5Y). When the tumor volume reached 250 mm3, the mice were randomized into SD group with standard diet and PBS treatment, KD group with ketogenic diet and PBS treatment, and CP+KD group with ketogenic diet and cyclophosphamide (60 mg·kg

resultsOn day 28 post tumor cell injection, the mice in KD and CP+KD groups could prolong the overall survival rates than that in SD group (

conclusionsKD has a strong anti-tumor effect in the xenograft mouse model possibly by regulating cell autophagy.

Indexed as

Diet, KetogenicNeuroblastoma3-Hydroxybutyric AcidAnimalsBlood GlucoseCell Line, TumorHumansMiceMice, Inbred BALB C3-Hydroxybutyric AcidBlood Glucoseautophagycyclophosphamidehuman neuroblastomaketogenic diet

Identifiers

PMID32895178
PMCPMC7429154
OpenAlexW3083862374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.