ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2020
[Acid-sensing ion channels differentially affect ictal-like and non-ictal-like epileptic activities of mouse hippocampal pyramidal neurons in acidotic extracellular pH].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the effects of acid-sensing ion channels (ASICs) on electrophysiological epileptic activities of mouse hippocampal pyramidal neurons in the extracellular acidotic condition.
methodsWe investigated effects of extracellular acidosis on epileptic activities induced by elevated extracellular K
resultsExtracellular acidosis significantly suppressed epileptic activities of the hippocampal neurons by converting ictal-like epileptic activities to non-ictal-like epileptic activities in both high [K
conclusionsASICs can differentially modulate ictal-like and non-ictallike epileptic activities via its direct actions on excitatory neurons.
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