ArticleDigestion2021
Long-Term Prognostic Predictors of Esophageal Squamous Cell Carcinoma Potentially Indicated for Endoscopic Submucosal Dissection.
Article in Digestion, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Prognostic value of pretreatment Controlling Nutritional Status score in esophageal cancer: a meta-analysis.Pathology oncology research : POR · 2023Pooled it
- Endoscopic Papillectomy for Ampullary Tumors in Older Patients: Balancing Oncologic Benefit and Geriatric Risk.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Review
- Mapping Two Decades of Research on Endoscopic Submucosal Dissection in Esophageal Cancer: A Bibliometric and Visual Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Impact of Sarcopenia on Elderly Patients Undergoing Endoscopic Resection: Scoping Review.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Article
- Risk Factors for Adverse Circulatory and Respiratory Events in Patients Undergoing Esophageal Endoscopic Submucosal Dissection Under Dexmedetomidine-Based Sedation.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2026Article
- Article
- Short- and long-term outcomes of endoscopic submucosal dissection for superficial pharyngeal squamous cell carcinoma in older adult patients.Surgical endoscopy · 2025Article
- Long-term outcomes of endoscopic resection of superficial esophageal squamous cell carcinoma in late-elderly patients.Journal of gastroenterology and hepatology · 2024Article
- Characteristics of Esophageal Squamous Cell Carcinomas Based on Circumferential Localization.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Management of esophageal neoplasms by endoscopic submucosal dissection: experience over 100 consecutive procedures.Clinical endoscopy · 2023Article
- Novel Photodynamic Therapy for Esophageal Squamous Cell Carcinoma following Radiotherapy.Life (Basel, Switzerland) · 2023Article
- Determinants of survival outcomes among esophageal cancer patients at a national referral hospital in Kenya.Chronic diseases and translational medicine · 2023Article
- Review
- Evaluation of long-term survival in patients with severe comorbidities after endoscopic submucosal dissection for esophageal squamous cell carcinoma.Surgical endoscopy · 2022Article
- The impact of the age-adjusted Charlson comorbidity index as a prognostic factor for endoscopic papillectomy in ampullary tumors.Journal of gastroenterology · 2022Article
- Usefulness of Nutrition and Inflammation Assessment Tools in Esophageal Cancer Treatment.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPatients with esophageal squamous cell carcinoma (ESCC) have various comorbidities. Thus, it is necessary to determine the appropriateness of performing treatment based on the patient's general condition.
aimThis study aimed to clarify the prognostic predictors of ESCC indicated for endoscopic submucosal dissection (ESD).
methodsThis retrospective study enrolled 241 patients with superficial ESCC endoscopically diagnosed as ESD-indicated lesions at the Nagoya University Hospital between January 2007 and December 2017. We evaluated the 3- and 5-year overall survival (OS) rates and prognostic predictors, such as the Prognostic Nutritional Index (PNI), Charlson Comorbidity Index (CCI), Psoas Muscle Index, and Controlling Nutritional Status score. Furthermore, we created a score-based classification using the prognostic predictors identified by multivariate analysis, and the 3- and 5-year OS rates were compared among the calculated scores.
resultsIn the multivariate analysis, PNI < 45 (hazard ratio [HR]: 2.39; 95% confidence interval [CI]: 1.28-4.46; p = 0.006) and CCI ≥ 3 (HR: 4.42; 95% CI: 2.40-8.12; p < 0.001) were significantly associated with the OS. Based on the HR, 0 and 1 were assigned to PNI and 0, 2, and 4 were assigned to CCI, and the score classification of 0-5 points was created. The 3- and 5-year OS rates in patients with a score 3 were significantly higher than in those with scores 4 and 5. As a result of scoring, the prognosis was stratified; the 3- and 5-year OS rates in patients with scores 4 and 5, that is, CCI ≥ 6, were clearly low, at approximately 10%.
conclusionsCCI and PNI can be prognostic predictors of patients with superficial ESCC indicated for ESD. Observation without ESD might be an acceptable strategy among patients with CCI ≥ 6.
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