Evidence map›Paper›PMID 32894757›Full record

ArticleAge and ageing2021

Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease.

Jilles M Fermont, Divya Mohan, Marie Fisk, Charlotte E Bolton, William Macnee, John R Cockcroft, Carmel McEniery, Jonathan Fuld, Joseph Cheriyan, Ruth Tal-Singer and 5 more

Abstract read
In one paragraph

Article in Age and ageing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jilles M FermontDivision of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK.
Divya MohanMedical Innovation, Value Evidence and Outcomes, GSK, Collegeville, PA, USA.
Marie FiskDivision of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK.
Charlotte E BoltonDivision of Respiratory Medicine and NIHR Nottingham BRC Respiratory Theme, University of Nottingham, Nottingham, UK.
William MacneeCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
John R CockcroftDepartment of Cardiology, Columbia University Medical Centre, New York, NY, USA.
Carmel McEnieryDivision of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK.
Jonathan FuldDepartment of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Joseph CheriyanDivision of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK.
Ruth Tal-SingerMedical Innovation, Value Evidence and Outcomes, GSK, Collegeville, PA, USA.
Hana MüllerovaGSK R&D, Uxbridge, UK.
Angela M WoodBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Ian B WilkinsonDivision of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK.
Michael I PolkeyDepartment of Respiratory Medicine, Royal Brompton Hospital, London, UK.
ERICA consortium

Funding

British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council MR/L003120/1Wellcome Trust
6 · The paper itself

Abstract

rationalechronic obstructive pulmonary disease (COPD) is a leading cause of mortality and common in older adults. The BODE Index is the most recognised mortality risk score in COPD but includes a 6-minute walk test (6MWT) that is seldom available in practise; the BODE Index may be better adopted if the 6MWT was replaced.

objectiveswe investigated whether a modified BODE Index in which 6MWT was replaced by an alternative measure of physical capacity, specifically the short physical performance battery (SPPB) or components, retained its predictive ability for mortality in individuals with COPD.

methodswe analysed 630 COPD patients from the ERICA cohort study for whom UK Office for National Statistics verified mortality data were available. Variables tested at baseline included spirometry, 6MWT, SPPB and its components (4-m gait speed test [4MGS], chair stand and balance). Predictive models were developed using stratified multivariable Cox regression, and assessed by C-indices and calibration plots with 10-fold cross-validation and replication.

resultsduring median 2 years of follow-up, 60 (10%) individuals died. There was no significant difference between the discriminative ability of BODE6MWT (C-index 0.709, 95% confidence interval [CI], 0.680-0.737), BODESPPB (C-index 0.683, 95% CI, 0.647-0.712), BODE4MGS (C-index 0.676, 95% CI, 0.643-0.700) and BODEBALANCE (C-index 0.686, 95% CI, 0.651-0.713) for predicting mortality.

conclusionsthe SPPB, and its 4MGS and balance components, can potentially be used as an alternative to the 6MWT in the BODE Index without significant loss of predictive ability in all-cause mortality.

Indexed as

Pulmonary Disease, Chronic ObstructiveAgedCohort StudiesExercise ToleranceGaitHumansPhysical Functional PerformanceSeverity of Illness IndexWalk Testbiomarkerschronic obstructive pulmonary diseasemortalityolder peopleskeletal muscle

Identifiers

PMID32894757
PMCPMC8098797

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.