Evidence map›Paper›PMID 32894697›Full record

ArticleAnnals of internal medicine2021

Four-Week Direct-Acting Antiviral Prophylaxis for Kidney Transplantation From Hepatitis C-Viremic Donors to Hepatitis C-Negative Recipients: An Open-Label Nonrandomized Study.

Christine M Durand, Brittany Barnaba, Sile Yu, Diane M Brown, Michael A Chattergoon, Nichole Bair, Fizza F Naqvi, Mark Sulkowski, Dorry L Segev, Niraj M Desai

Registry-linked trialAbstract readLetter
In one paragraph

Article in Annals of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04575896 (An Open-label, Non-randomized Pilot Study to Determine the Safety and Efficacy of Two Weeks of Fixed-dose Glecaprevir and Pibrentasvir as Pre- and Post-exposure Prophylactic Therapy), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04575896 phase4completednot on this map

An Open-label, Non-randomized Pilot Study to Determine the Safety and Efficacy of Two Weeks of Fixed-dose Glecaprevir and Pibrentasvir as Pre- and Post-exposure Prophylactic Therapy

TypeinterventionalSponsorJohns Hopkins UniversityRan2020 to 2023Enrolled10ConditionsEnd Stage Renal Disease, Hepatitis CArmsGlecaprevir/pibrentasvir
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Prophylactic 2-week glecaprevir/pibrentasvir in hepatitis C positive-to-negative kidney transplantation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  7. Article
  8. Twelve-month kidney and liver outcomes of kidney transplantation from Hepatitis C Viremic deceased donors to aviremic recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2024
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Kidney Transplantation From Hepatitis-C Viraemic Donors:Considerations for Practice in the United Kingdom.Transplant international : official journal of the European Society for Organ Transplantation · 2022
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christine M DurandJohns Hopkins University School of Medicine, Baltimore, Maryland (C.M.D., B.B., S.Y., D.M.B., M.A.C., N.B., F.F.N., M.S., D.L.S., N.M.D.).ORCID 0000-0003-2605-9257
Brittany BarnabaJohns Hopkins University School of Medicine, Baltimore, Maryland (C.M.D., B.B., S.Y., D.M.B., M.A.C., N.B., F.F.N., M.S., D.L.S., N.M.D.).
Sile YuJohns Hopkins University School of Medicine, Baltimore, Maryland (C.M.D., B.B., S.Y., D.M.B., M.A.C., N.B., F.F.N., M.S., D.L.S., N.M.D.).ORCID 0000-0002-9956-2526
Diane M BrownJohns Hopkins University School of Medicine, Baltimore, Maryland (C.M.D., B.B., S.Y., D.M.B., M.A.C., N.B., F.F.N., M.S., D.L.S., N.M.D.).
Michael A ChattergoonJohns Hopkins University School of Medicine, Baltimore, Maryland (C.M.D., B.B., S.Y., D.M.B., M.A.C., N.B., F.F.N., M.S., D.L.S., N.M.D.).
Nichole BairJohns Hopkins University School of Medicine, Baltimore, Maryland (C.M.D., B.B., S.Y., D.M.B., M.A.C., N.B., F.F.N., M.S., D.L.S., N.M.D.).
Fizza F NaqviJohns Hopkins University School of Medicine, Baltimore, Maryland (C.M.D., B.B., S.Y., D.M.B., M.A.C., N.B., F.F.N., M.S., D.L.S., N.M.D.).
Mark SulkowskiJohns Hopkins University School of Medicine, Baltimore, Maryland (C.M.D., B.B., S.Y., D.M.B., M.A.C., N.B., F.F.N., M.S., D.L.S., N.M.D.).ORCID 0000-0002-2145-6352
Dorry L SegevJohns Hopkins University School of Medicine, Baltimore, Maryland (C.M.D., B.B., S.Y., D.M.B., M.A.C., N.B., F.F.N., M.S., D.L.S., N.M.D.).
Niraj M DesaiJohns Hopkins University School of Medicine, Baltimore, Maryland (C.M.D., B.B., S.Y., D.M.B., M.A.C., N.B., F.F.N., M.S., D.L.S., N.M.D.).ORCID 0000-0002-0457-3506

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Optimal Antiretroviral Therapy During Bone Marrow Transplant in HIV-1 InfectionK23CA177321 · NCI · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE · 2014 to 2018
$808k
NCI NIH HHS K23 CA177321NIAID NIH HHS P30 AI094189NIDDK NIH HHS K24 DK101828
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Tissue DonorsAdultAgedAntiviral AgentsFemaleHepacivirusHepatitis C AntibodiesHepatitis C, ChronicHumansKidney TransplantationMaleMiddle AgedAntiviral AgentsHepatitis C Antibodies

Identifiers

PMID32894697
PMCPMC8288461

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.