Evidence map›Paper›PMID 32894500›Full record

ArticleMolecular neurobiology2021

Potential Mechanism of Cellular Uptake of the Excitotoxin Quinolinic Acid in Primary Human Neurons.

Nady Braidy, Hayden Alicajic, David Pow, Jason Smith, Bat-Erdene Jugder, Bruce J Brew, Joseph A Nicolazzo, Gilles J Guillemin

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Nady BraidyCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia. n.braidy@unsw.edu.au.ORCID http://orcid.org/0000-0002-0497-5572
Hayden AlicajicNeuropharmacology group, MND and Neurodegenerative diseases Research Centre, Macquarie University, Sydney, NSW, 2019, Australia.
David PowUniversity of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.
Jason SmithDepartment of Chemistry and Biomolecular sciences, Macquarie University, Sydney, NSW, Australia.
Bat-Erdene JugderSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
Bruce J BrewSt Vincent's Centre for Applied Medical Research, Sydney, Australia.
Joseph A NicolazzoDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Gilles J GuilleminNeuropharmacology group, MND and Neurodegenerative diseases Research Centre, Macquarie University, Sydney, NSW, 2019, Australia. gilles.guillemin@mq.edu.au.
Macquarie University · AUHuzhou University · CNMonash University · AUSt Vincent's Hospital Melbourne · AUThe University of Queensland · AUUNSW Sydney · AU

Funding

Centre of Excellence in Cognition and its Disorders, Australian Research Council DE170100628National Health and Medical Research Council APP1128849
6 · The paper itself

Abstract

In Alzheimer's disease (AD), excessive amounts of quinolinic acid (QUIN) accumulate within the brain parenchyma and dystrophic neurons. QUIN also regulates glutamate uptake into neurons, which may be due to modulation of Na

Indexed as

EndocytosisCells, CulturedExcitatory Amino Acid Transporter 1Excitatory Amino Acid Transporter 3FetusHumansKineticsLysosomal-Associated Membrane Protein 2Models, MolecularNeuronsNeurotoxinsQuinolinic AcidTime FactorsExcitatory Amino Acid Transporter 1Excitatory Amino Acid Transporter 3LAMP2 protein, humanLysosomal-Associated Membrane Protein 2NeurotoxinsQuinolinic AcidSLC1A1 protein, humanSLC1A3 protein, humanEAAT3GlutamateKynurenine pathwayNeuronsQuinolinic acid

Identifiers

PMID32894500
OpenAlexW3083247166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.