Evidence map›Paper›PMID 32894462›Full record

ArticleDoklady. Biochemistry and biophysics2020

The Anxiolytic Effect of the Neuropeptide Cycloprolylglycine Is Mediated by AMPA and TrkB Receptors.

T A Gudasheva, P Yu Povarnina, K N Koliasnikova, A G Alyaeva, O N Vorontsova, S B Seredenin

Abstract read
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Article in Doklady. Biochemistry and biophysics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

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  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

T A GudashevaZakusov Research Institute of Pharmacology, Moscow, Russia. tata-sosnovka@mail.ru.
P Yu PovarninaZakusov Research Institute of Pharmacology, Moscow, Russia.
K N KoliasnikovaZakusov Research Institute of Pharmacology, Moscow, Russia.
A G AlyaevaZakusov Research Institute of Pharmacology, Moscow, Russia.
O N VorontsovaZakusov Research Institute of Pharmacology, Moscow, Russia.
S B SeredeninZakusov Research Institute of Pharmacology, Moscow, Russia.
Institute of Pharmacology Russian Academy of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously we have shown that the neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors and assumed that the pharmacological effects of CPG are associated with the brain neurotrophic factor. In this paper, we have first demonstrated that DNQX, an inhibitor of AMPA receptors, and K252A, an ihibitor of Trk receptors, prevented the anxiolytic effect of CPG, which confirms the formulated hypothesis.

Indexed as

AnimalsAnti-Anxiety AgentsAnxiety DisordersBrain-Derived Neurotrophic FactorCarbazolesEnzyme InhibitorsExcitatory Amino Acid AntagonistsIndole AlkaloidsMaleMembrane GlycoproteinsMiceMice, Inbred BALB CPeptides, CyclicProtein-Tyrosine KinasesQuinoxalinesReceptors, AMPAAnti-Anxiety AgentsBrain-Derived Neurotrophic FactorCarbazolescyclo(prolylglycyl)Enzyme InhibitorsExcitatory Amino Acid AntagonistsFG 9041Indole AlkaloidsMembrane GlycoproteinsNtrk2 protein, mousePeptides, CyclicProtein-Tyrosine KinasesQuinoxalinesReceptors, AMPAReceptor, trkBstaurosporine aglyconeAMPAanxiolytic activitybrain derived neurotrophic factor (BDNF)cyclo-L-prolyl-glycineTrkB

Identifiers

PMID32894462
OpenAlexW3084174103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.