Evidence map›Paper›PMID 32894460›Full record

ArticleDoklady. Biochemistry and biophysics2020

Comparative Analysis of Long Noncoding RNA Expression in Human Hepatocyte Cell Lines and Liver.

O Y Burenina, T S Zatsepin, E F Kim, A V Metelin, D A Skvortsov, M P Rubtsova, O A Dontsova

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

O Y BureninaCenter of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia. alunit@inbox.ru.
T S ZatsepinCenter of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.
E F KimPetrovsky National Research Centre of Surgery, Moscow, Russia.
A V MetelinPetrovsky National Research Centre of Surgery, Moscow, Russia.
D A SkvortsovBelozersky Institute of Physico-Chemical Biology and Chemistry Department, Moscow State University, Moscow, Russia.
M P RubtsovaCenter of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.
O A DontsovaCenter of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.
Lomonosov Moscow State University · RURussian Scientific Center of Surgery · RUSkolkovo Institute of Science and Technology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) are promising biomarkers and potential targets for liver cancer therapy. Stable hepatocyte lines are used in vitro to investigate functions of lncRNAs which amount in cell fluctuates during carcinogenesis. For the first time we compared gene expression of known lncRNAs in human conditional normal liver cells HepaRG and cancer cell lines Huh7 and HepG2. We showed that relative amounts of these lncRNAs in HepaRG are close to analogous variables measured for liver samples from healthy donors. Obtained data demonstrate exclusive peculiarities of HepaRG and confirm its reasonable application as a model of normal human hepatocytes for studying functions of lncRNAs.

Indexed as

Carcinoma, HepatocellularCells, CulturedHepatocytesHep G2 CellsHumansLiverLiver NeoplasmsRNA, Long NoncodingRNA, MessengerRNA, Long NoncodingRNA, MessengerHepaRGliver cancerКeywords: long noncoding RNAs

Identifiers

PMID32894460
OpenAlexW3083817170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.