Evidence map›Paper›PMID 32894459›Full record

ArticleDoklady. Biochemistry and biophysics2020

Influence of Internal and External Factors on the Production of Cytokines by Peripheral Blood Cells in Breast Cancer.

A I Autenshlyus, K I Davletova, E S Mikhaylova, A V Proskura, N A Varaksin, A P Bogachuk, S V Sidorov, V V Lyakhovich, V M Lipkin

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

A I AutenshlyusNovosibirsk State Medical University, Novosibirsk, Russia. lpciip@211.ru.
K I DavletovaNovosibirsk State Medical University, Novosibirsk, Russia.
E S MikhaylovaNovosibirsk State Medical University, Novosibirsk, Russia.
A V ProskuraInstitute of Molecular Biology and Biophysics, Subdivision of Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
N A VaraksinAO Vector-Best, Novosibirsk, Russia.
A P BogachukShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
S V SidorovNovosibirsk State University, Novosibirsk, Russia.
V V LyakhovichInstitute of Molecular Biology and Biophysics, Subdivision of Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
V M LipkinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Institute of Molecular Biology and Biophysics · RUInstitute of Bioorganic Chemistry · RUFederal Research Center of Fundamental and Translational Medicine · RUNovosibirsk State Medical University · RUNovosibirsk State University · RUState Research Center of Virology and Biotechnology VECTOR · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The article focuses on the influence of human leukemia differentiation factor (HLDF), carcinoembryonic antigen (CEA), and polyclonal activators (PA) on cytokine production by peripheral blood cells in breast cancer and benign breast diseases. It was found that the influence of internal factors on the production of cytokines by the peripheral blood cells is associated with lymphatic metastasis (CEA: IL-10; HLDF: IL-6, IL-1β, TNF-α, and G-CSF). One special circumstance was that there were no differences between the production of cytokines by peripheral blood cells in the patients with breast cancer compared to the patients with benign breast diseases with a high risk of malignant transformation. This is evidence of the functional similarity of peripheral blood cells in patients with these conditions. Cytokine production under the influence of PA was different only in case of TNF-α in all study groups.

Indexed as

Biomarkers, TumorBreast NeoplasmsCytokinesFemaleHumansInterleukin-1betaInterleukin-6Lymphatic MetastasisNeoplasm InvasivenessTumor Cells, CulturedTumor Necrosis Factor-alphaBiomarkers, TumorCytokinesIL6 protein, humanInterleukin-1betaInterleukin-6Tumor Necrosis Factor-alphabreast cancercarcinoembryonic antigencytokinesHLDFpolyclonal activators

Identifiers

PMID32894459
OpenAlexW3084118208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.