ArticleTranslational stroke research2021
Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment.
Article in Translational stroke research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Arterial stiffness moderates the link between NfL and cognition: The IGNITE study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Magnetic Resonance Imaging-Based Cortical and Subcortical Volumetric Changes in Alzheimer's Disease: Association with Clinical Severity.Diagnostics (Basel, Switzerland) · 2026Article
- Dysfunction of hippocampal cells and its role in cognitive impairment.Neural regeneration research · 2026Article
- MCC950 suppresses NLRP3-dependent neuroinflammation and ameliorates cognitive decline in a rat model of cerebral small vessel disease.Neural regeneration research · 2026Article
- Microglial reactivity predicts hippocampal, but not global, atrophy in cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Transcriptomic signatures of gray matter volume loss in cerebral small vessel disease.BMC neurology · 2026Article
- Radiomics models identifying dementia in patients with normal age-related hippocampal atrophy: a study based on machine learning.BMC geriatrics · 2025Article
- Preliminary study on changes in volume and functional connectivity of hippocampal subregions in patients with diabetic retinopathy.Brain imaging and behavior · 2025Article
- Effect of -deficiency constitution on cognitive impairment in cerebral small vessel disease and its neuroimaging mechanism.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Blood-brain barrier integrity disruption is associated with both chronic vascular risk factors and white matter hyperintensities.The journal of prevention of Alzheimer's disease · 2025Article
- Prediction models for cognitive impairment in middle-aged patients with cerebral small vessel disease.Frontiers in neurology · 2025Article
- Alterations of contralesional hippocampal subfield volumes and relations to cognitive functions in patients with unilateral stroke.Brain and behavior · 2024Article
- Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Association Between Hippocampal Volumes and Cognition in Cerebral Amyloid Angiopathy.Neurology · 2024Article
- Linear brain measurement: a new screening method for cognitive impairment in elderly patients with cerebral small vessel disease.Frontiers in neurology · 2024Article
- Unraveling the link: white matter damage, gray matter atrophy and memory impairment in patients with subcortical ischemic vascular disease.Frontiers in neuroscience · 2024Article
- Altered hippocampal subfield volumes in major depressive disorder with and without anhedonia.BMC psychiatry · 2023Article
- Role of Estrogen-Related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Altered brain spontaneous activity in patients with cerebral small vessel disease using the amplitude of low-frequency fluctuation of different frequency bands.Frontiers in neuroscience · 2023Article
- Effects of white matter hyperintensities distribution and clustering on late-life cognitive impairment.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
To investigate patterns of hippocampal subfield atrophy among patients with amnestic mild cognitive impairment, stratified by severity of small vessel disease (SVD) and corresponding associations with cognitive domains. One hundred seventy-six MCI subjects (mean age = 65.56 years, SD = 8.77) underwent neuropsychological assessments and magnetic resonance imaging. SVD was rated 0 (no SVD), 1 (mild SVD) and 2 (moderate to severe SVD) based on load of white matter hyperintensities (WMH) and lacunes. Demographics, cerebrovascular risk factors, grey and white matter volumes and hippocampal subfield atrophies were compared across SVD severity through ANCOVA analyses. Subjects were categorized into positive or negative SVD-hippocampal subfield atrophy (HSA) and influence of positive SVD-HSA on episodic memory and frontal executive function was evaluated through ANCOVA analyses. All analyses corrected for covariates and bias-corrected bootstrap estimation with 1000 resamples was applied with Bonferroni correction. Hippocampal subfield atrophy worsened with increasing SVD severity. Positive SVD-HSA was characterised by significant atrophy in the subiculum, CA1, CA4, molecular layer and dentate gyrus. Greater atrophy was seen with moderate to severe SVD compared to mild SVD in these subfields. Atrophy in the five subfields of SVD-HSA was significantly associated with poor episodic memory and frontal executive function. Presence and burden of SVD influences the pattern and severity of hippocampal subfield atrophy. SVD-related hippocampal subfield atrophy is associated with poorer episodic memory and frontal executive function in mild cognitive impairment.
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