Evidence map›Paper›PMID 32894376›Full record

ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2020

Race and sex differences in cardiovascular autonomic regulation.

Maureen C Farrell, Richard J Giza, Cyndya A Shibao

Open access · greenAbstract readReview
In one paragraph

Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Cardiac autonomic function in young, healthy adults: Influence of race and sex.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Racial Differences in Blood Pressure and Autonomic Recovery Following Acute Supramaximal Exercise in Women.International journal of environmental research and public health · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Pre-Hypertension in Adolescents: A New Old Issue.Arquivos brasileiros de cardiologia · 2021
    Article
  18. Article
  19. Orthostatic responses in Caucasian, South Asian, and Middle Eastern women.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  20. Factors contributing to racial differences in neurogenic orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Maureen C FarrellDrexel University College of Medicine, Philadelphia, PA, USA.ORCID 0000-0003-4728-0233
Richard J GizaDrexel University College of Medicine, Philadelphia, PA, USA.
Cyndya A ShibaoDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 506 Robinson Research Building, Nashville, TN, 37232-6602, USA. Cyndya.shibao@vanderbilt.edu.ORCID 0000-0002-4518-6801
Drexel University · USVanderbilt University Medical Center · US

Funding

Phase 2 Norepinephrine Transporter Blockade, Autonomic Failure IND117394 12/28/12R01FD004778 · FDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KAUFMANN, HORACIO, SHIBAO, CYNDYA ADRIANA · 2016 to 2019
$1.6M
FDA HHS R01 FD004778
6 · The paper itself

Abstract

Racial and ethnic differences in cardiovascular morbidity and mortality persist despite advances in risk factor identification and implementation of evidence-based treatment strategies. African American men and women are disproportionately affected by cardiovascular risk factors, particularly hypertension. In this context, previous studies have identified sex and racial differences in autonomic cardiovascular regulation which may contribute to the development of hypertension and its high morbidity burden among African Americans. In this review, we provide a comprehensive evaluation of the potential pathophysiological mechanisms of blood pressure control and their differences based on sex and race. These mechanisms include obesity-induced sympathetic activation, sympatho-vascular transduction, baroreflex sensitivity and adrenoreceptor vascular sensitivity, which have been the subjects of prior investigation in this field. Understanding the racial differences in the pathophysiology of hypertension and its co-morbid conditions would allow us to implement better treatment strategies tailored to African Americans, with the ultimate goal of reducing cardiovascular mortality in this population.

Indexed as

Cardiovascular SystemHypertensionAutonomic Nervous SystemBaroreflexBlood PressureFemaleHumansMaleSex CharacteristicsAfrican AmericansAutonomic nervous systemBlood pressureHeart rate variabilitySympathetic transduction

Identifiers

PMID32894376
PMCPMC7584374
OpenAlexW3083959505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.